ArticleEukaryotic cell2004
Hemoglobin regulates expression of an activator of mating-type locus alpha genes in Candida albicans.
Article in Eukaryotic cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025Review
- White-opaque switching inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Unraveling HowJournal of fungi (Basel, Switzerland) · 2020Review
- White-opaque Switching in Different Mating Type-like Locus Gene Types of ClinicalChinese medical journal · 2016Article
- Article
- Article
- Hbr1 Activates and Represses Hyphal Growth in Candida albicans and Regulates Fungal Morphogenesis under Embedded Conditions.PloS one · 2015Article
- The cryptic sexual strategies of human fungal pathogens.Nature reviews. Microbiology · 2014Review
- The role of phenotypic switching in the basic biology and pathogenesis of Candida albicans.Journal of oral microbiology · 2014Review
- Unisexual reproduction.Advances in genetics · 2014Review
- Does stress induce (para)sex? Implications for Candida albicans evolution.Trends in genetics : TIG · 2012Article
- ATP binding to hemoglobin response gene 1 protein is necessary for regulation of the mating type locus in Candida albicans.The Journal of biological chemistry · 2011Article
- Dur3 is the major urea transporter in Candida albicans and is co-regulated with the urea amidolyase Dur1,2.Microbiology (Reading, England) · 2011Article
- Candida albicans heme oxygenase and its product CO contribute to pathogenesis of candidemia and alter systemic chemokine and cytokine expression.Free radical biology & medicine · 2010Article
- Sexual reproduction in the Candida clade: cryptic cycles, diverse mechanisms, and alternative functions.Cellular and molecular life sciences : CMLS · 2010Review
- Regulation of white-opaque switching in Candida albicans.Medical microbiology and immunology · 2010Review
- Candida albicans cell wall proteins.Microbiology and molecular biology reviews : MMBR · 2008Review
- Environmental induction of white-opaque switching in Candida albicans.PLoS pathogens · 2008Article
- Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Detection of Candida albicans in oral squamous cell carcinoma by fluorescence staining technique.Dental research journalArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Phenotypic switching from the white to the opaque phase is a necessary step for mating in the pathogenic fungus Candida albicans. Suppressing switching during vascular dissemination of the organism may be advantageous, because opaque cells are more susceptible to host defenses. A repressor of white-opaque switching, HBR1 (hemoglobin response gene 1), was identified based on its specific induction following growth in the presence of exogenous hemoglobin. Deletion of a single HBR1 allele allowed opaque phase switching and mating competence, accompanied by a lack of detectable MTL alpha1 and alpha2 gene expression and enhanced MTLa1 gene expression. Conversely, overexpression of Hbr1p or exposure to hemoglobin increased MTLalpha gene expression. The a1/alpha2 repressed target gene CAG1 was derepressed in the same mutant in a hemoglobin-sensitive manner. Regulation of CAG1 by hemoglobin required an intact MTLa1 gene. Several additional Mtlp targets were perturbed in HBR1 mutants in a manner consistent with commitment to an a mating phenotype, including YEL007w, MFalpha, HST6, and RAM2. Therefore, Hbr1 is part of a host factor-regulated signaling pathway that controls white-opaque switching and mating in the absence of allelic deletion at the MTL locus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.