ArticleEukaryotic cell2004
Candida albicans Rim13p, a protease required for Rim101p processing at acidic and alkaline pHs.
Article in Eukaryotic cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 97 citations in OpenAlex.
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- Unexpected Inhibitory Effect of Octenidine Dihydrochloride onAntibiotics (Basel, Switzerland) · 2023Article
- Candida albicans Hyphal Morphogenesis within Macrophages Does Not Require Carbon Dioxide or pH-Sensing Pathways.Infection and immunity · 2023Article
- Calpains in cyanobacteria and the origin of calpains.Scientific reports · 2022Article
- The regulation of hyphae growth inVirulence · 2020Review
- The ESCRT System Plays an Important Role in the Germination in Candida albicans by Regulating the Expression of Hyphal-Specific Genes and the Localization of Polarity-Related Proteins.Mycopathologia · 2020Article
- Linking Sfl1 Regulation of Hyphal Development to Stress Response Kinases in Candida albicans.mSphere · 2020Article
- Transcriptome analysis of the dimorphic transition induced by pH change and lipid biosynthesis in Trichosporon cutaneum.Journal of industrial microbiology & biotechnology · 2020Article
- How to Use a Mutant Library to Identify Genes Required for Biofilm Formation in the PathogenicUJEMI+ · 2020Article
- Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection.Cell host & microbe · 2019Article
- Functional diversity in the pH signaling pathway: an overview of the pathway regulation in Neurospora crassa.Current genetics · 2018Review
- The Rim Pathway Mediates Antifungal Tolerance in Candida albicans through Newly Identified Rim101 Transcriptional Targets, Including Hsp90 and Ipt1.Antimicrobial agents and chemotherapy · 2018Article
- Differences in the Characteristics and Pathogenicity ofFrontiers in microbiology · 2018Article
- Filamentation Involves Two Overlapping, but Distinct, Programs of Filamentation in the Pathogenic FungusG3 (Bethesda, Md.) · 2017Article
- Anticandidal activity of hetero-dinuclear copper(II) Mn(II) Schiff base and its potential action of the mechanism.World journal of microbiology & biotechnology · 2017Article
- Candida albicans cell-type switching and functional plasticity in the mammalian host.Nature reviews. Microbiology · 2017Review
- Morphology Changes in Human Fungal Pathogens upon Interaction with the Host.Journal of fungi (Basel, Switzerland) · 2017Article
- Calpain research for drug discovery: challenges and potential.Nature reviews. Drug discovery · 2016Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Candida albicans is an important commensal of mucosal surfaces that is also an opportunistic pathogen. This organism colonizes a wide range of host sites that differ in pH; thus, it must respond appropriately to this environmental stress to survive. The ability to respond to neutral-to-alkaline pHs is governed in part by the RIM101 signal transduction pathway. Here we describe the analysis of C. albicans Rim13p, a homolog of the Rim13p/PalB calpain-like protease member of the RIM101/pacC pathway from Saccharomyces cerevisiae and Aspergillus nidulans, respectively. RIM13, like other members of the RIM101 pathway, is required for alkaline pH-induced filamentation and growth under extreme alkaline conditions. Further, our studies suggest that the RIM101 pathway promotes pH-independent responses, including resistance to high concentrations of lithium and to the drug hygromycin B. RIM13 encodes a calpain-like protease, and we found that Rim101p undergoes a Rim13p-dependent C-terminal proteolytic processing event at neutral-to-alkaline pHs, similar to that reported for S. cerevisiae Rim101p and A. nidulans PacC. However, we present evidence that suggests that C. albicans Rim101p undergoes a novel processing event at acidic pHs that has not been reported in either S. cerevisiae or A. nidulans. Thus, our results provide a framework to understand how the C. albicans Rim101p processing pathway promotes alkaline pH-independent processes.
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