ArticleEukaryotic cell2004
Cdc42p GTPase regulates the budded-to-hyphal-form transition and expression of hypha-specific transcripts in Candida albicans.
Article in Eukaryotic cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Review
- The Role of Secretory Pathways inJournal of fungi (Basel, Switzerland) · 2020Review
- Regulation ofJournal of fungi (Basel, Switzerland) · 2019Review
- Rsr1 focuses Cdc42 activity at hyphal tips and promotes maintenance of hyphal development in Candida albicans.Eukaryotic cell · 2013Article
- Ras1 acts through duplicated Cdc42 and Rac proteins to regulate morphogenesis and pathogenesis in the human fungal pathogen Cryptococcus neoformans.PLoS genetics · 2013Article
- Ras-Mediated Signal Transduction and Virulence in Human Pathogenic Fungi.Fungal genomics & biology · 2012Article
- Killing of Candida albicans filaments by Salmonella enterica serovar Typhimurium is mediated by sopB effectors, parts of a type III secretion system.Eukaryotic cell · 2011Article
- Candida albicans Ume6, a filament-specific transcriptional regulator, directs hyphal growth via a pathway involving Hgc1 cyclin-related protein.Eukaryotic cell · 2010Article
- Two CDC42 paralogues modulate Cryptococcus neoformans thermotolerance and morphogenesis under host physiological conditions.Molecular microbiology · 2010Article
- Depletion of the cullin Cdc53p induces morphogenetic changes in Candida albicans.Eukaryotic cell · 2009Article
- Activation of Rac1 by the guanine nucleotide exchange factor Dck1 is required for invasive filamentous growth in the pathogen Candida albicans.Molecular biology of the cell · 2008Article
- Role of actin cytoskeletal dynamics in activation of the cyclic AMP pathway and HWP1 gene expression in Candida albicans.Eukaryotic cell · 2007Article
- Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans.Microbiology and molecular biology reviews : MMBR · 2007Review
- Candida albicans Rho-type GTPase-encoding genes required for polarized cell growth and cell separation.Eukaryotic cell · 2007Article
- Regulation of Cdc42 GTPase activity in the formation of hyphae in Candida albicans.Molecular biology of the cell · 2007Article
- Effects of low-shear modeled microgravity on cell function, gene expression, and phenotype in Saccharomyces cerevisiae.Applied and environmental microbiology · 2006Article
- Rac1 and Cdc42 have different roles in Candida albicans development.Eukaryotic cell · 2006Article
- Hyphal guidance and invasive growth in Candida albicans require the Ras-like GTPase Rsr1p and its GTPase-activating protein Bud2p.Eukaryotic cell · 2005Article
- Regulation of the Cdc42/Cdc24 GTPase module during Candida albicans hyphal growth.Eukaryotic cell · 2005Article
- Small-molecule inhibitors of the budded-to-hyphal-form transition in the pathogenic yeast Candida albicans.Antimicrobial agents and chemotherapy · 2005Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The yeast Candida albicans is a major opportunistic pathogen of immunocompromised individuals. It can grow in several distinct morphological states, including budded and hyphal forms, and the ability to make the dynamic transition between these forms is strongly correlated with virulence. Recent studies implicating the Cdc42p GTPase in hypha formation relied on cdc42 mutations that affected the mitotic functions of the protein, thereby precluding any substantive conclusions about the specific role of Cdc42p in the budded-to-hypha-form transition and virulence. Therefore, we took advantage of several Saccharomyces cerevisiae cdc42 mutants that separated Cdc42p's mitotic functions away from its role in filamentous growth. The homologous cdc42-S26I, cdc42-E100G, and cdc42-S158T mutations in C. albicans Cdc42p caused a dramatic defect in the budded-to-hypha-form transition in response to various hypha-inducing signals without affecting normal budded growth, strongly supporting the conclusion that Cdc42p has an integral function in orchestrating the morphological transition in C. albicans. In addition, the cdc42-S26I and cdc42-E100G mutants demonstrated a reduced ability to damage endothelial cells, a process that is strongly correlated to virulence. The three mutants also had reduced expression of several hypha-specific genes, including those under the regulation of the Efg1p transcription factor. These data indicate that Cdc42p-dependent signaling pathways regulate the budded-to-hypha-form transition and the expression of hypha-specific genes.
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