ArticleEukaryotic cell2004
Homing endonucleases encoded by germ line-limited genes in Tetrahymena thermophila have APETELA2 DNA binding domains.
Article in Eukaryotic cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- A recently evolved nonautonomous DNA transposon shapes DREB-related DRF1 gene architecture in Triticeae.The plant genome · 2026Article
- Programmed chromosome fragmentation in ciliated protozoa: multiple means to chromosome ends.Microbiology and molecular biology reviews : MMBR · 2023Review
- Genome-Wide Identification and Expression Analysis of AP2/ERF Transcription Factor Related to Drought Stress in Cultivated Peanut (Frontiers in genetics · 2021Article
- Identification and analysis of micro-exons in AP2/ERF and MADS gene families.FEBS open bio · 2020Article
- Article
- Regulation of Apetala2/Ethylene Response Factors in Plants.Frontiers in plant science · 2017Review
- Fusion of a superfamily 1 helicase and an inactivated DNA polymerase is a signature of common evolutionary history of Polintons, polinton-like viruses, Tlr1 transposons and transpovirons.Virus evolution · 2016Article
- Genome-wide analysis of AP2/ERF transcription factors in carrot (Daucus carota L.) reveals evolution and expression profiles under abiotic stress.Molecular genetics and genomics : MGG · 2015Article
- The Cryptosporidium parvum ApiAP2 gene family: insights into the evolution of apicomplexan AP2 regulatory systems.Nucleic acids research · 2014Article
- The floral homeotic protein APETALA2 recognizes and acts through an AT-rich sequence element.Development (Cambridge, England) · 2012Article
- AP2/ERF Transcription Factor in Rice: Genome-Wide Canvas and Syntenic Relationships between Monocots and Eudicots.Evolutionary bioinformatics online · 2012Article
- Genomes of the T4-related bacteriophages as windows on microbial genome evolution.Virology journal · 2010Review
- The construction and use of log-odds substitution scores for multiple sequence alignment.PLoS computational biology · 2010Article
- The CRF domain defines cytokinin response factor proteins in plants.BMC plant biology · 2010Article
- Phylogenomic analysis of the GIY-YIG nuclease superfamily.BMC genomics · 2006Article
- The highly conserved family of Tetrahymena thermophila chromosome breakage elements contains an invariant 10-base-pair core.Eukaryotic cell · 2006Article
- Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains.Nucleic acids research · 2005Article
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three insertion elements were previously found in a family of germ line-limited mobile elements, the Tlr elements, in the ciliate Tetrahymena. Each of the insertions contains an open reading frame (ORF). Sequence analysis of the deduced proteins encoded by the elements suggests that they are homing endonucleases. The genes are designated TIE1-1, TIE2-1, and TIE3-1 for Tetrahymena insertion-homing endonuclease. The endonuclease motif occupies the amino terminal half of each TIE protein. The C-terminal regions of the proteins are similar to the APETELA2 DNA binding domain of plant transcription factors. The TIE1 and TIE3 elements belong to families of repeated sequences in the germ line micronuclear genome. Comparison of the genes and the deduced proteins they encode suggests that there are at least two distinct families of homing endonuclease genes, each of which appears to be preferentially associated with a specific region of the Tlr elements. The TIE1 and TIE3 elements and their cognates undergo programmed elimination from the developing somatic macronucleus of Tetrahymena. The possible role of homing endonuclease-like genes in the DNA breakage step in developmentally programmed DNA elimination in Tetrahymena is discussed.
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