ArticleEukaryotic cell2004
The Kip3-like kinesin KipB moves along microtubules and determines spindle position during synchronized mitoses in Aspergillus nidulans hyphae.
Article in Eukaryotic cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
- Experimental evidence for the functional importance and adaptive advantage of A-to-I RNA editing in fungi.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Potent microtubule-depolymerizing activity of a mitotic Kif18b-MCAK-EB network.Journal of cell science · 2023Article
- Kinesin Motors in the Filamentous Basidiomycetes in Light of theJournal of fungi (Basel, Switzerland) · 2022Review
- Bioenergetics of theBiomolecules · 2020Article
- Proteome Analyses RevealACS omega · 2020Article
- Three-Dimensional Optical Tweezers Tracking Resolves Random Sideward Steps of the Kinesin-8 Kip3.Biophysical journal · 2018Article
- Nuclear movement in fungi.Seminars in cell & developmental biology · 2018Review
- Fungal Morphogenesis, from the Polarized Growth of Hyphae to Complex Reproduction and Infection Structures.Microbiology and molecular biology reviews : MMBR · 2018Review
- A Tubulin Binding Switch Underlies Kip3/Kinesin-8 Depolymerase Activity.Developmental cell · 2017Article
- Mechanisms of Chromosome Congression during Mitosis.Biology · 2017Review
- Role and regulation of kinesin-8 motors through the cell cycle.Systems and synthetic biology · 2014Article
- Spatial control of microtubule length and lifetime by opposing stabilizing and destabilizing functions of Kinesin-8.Current biology : CB · 2014Article
- Move in for the kill: motile microtubule regulators.Trends in cell biology · 2012Review
- Lis1 is an initiation factor for dynein-driven organelle transport.The Journal of cell biology · 2012Article
- The Aspergillus nidulans CENP-E kinesin KipA is able to dimerize and to move processively along microtubules.Current genetics · 2011Article
- The Aspergillus nidulans nucA(EndoG) homologue is not involved in cell death.Eukaryotic cell · 2011Article
- Aspergillus myosin-V supports polarized growth in the absence of microtubule-based transport.PloS one · 2011Article
- In vivo analysis of the functions of gamma-tubulin-complex proteins.Journal of cell science · 2009Article
- Kinesin-8 from fission yeast: a heterodimeric, plus-end-directed motor that can couple microtubule depolymerization to cargo movement.Molecular biology of the cell · 2009Article
- The Aspergillus nidulans kinesin-3 UncA motor moves vesicles along a subpopulation of microtubules.Molecular biology of the cell · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kinesins are motor proteins which are classified into 11 different families. We identified 11 kinesin-like proteins in the genome of the filamentous fungus Aspergillus nidulans. Relatedness analyses based on the motor domains grouped them into nine families. In this paper, we characterize KipB as a member of the Kip3 family of microtubule depolymerases. The closest homologues of KipB are Saccharomyces cerevisiae Kip3 and Schizosaccharomyces pombe Klp5 and Klp6, but sequence similarities outside the motor domain are very low. A disruption of kipB demonstrated that it is not essential for vegetative growth. kipB mutant strains were resistant to high concentrations of the microtubule-destabilizing drug benomyl, suggesting that KipB destabilizes microtubules. kipB mutations caused a failure of spindle positioning in the cell, a delay in mitotic progression, an increased number of bent mitotic spindles, and a decrease in the depolymerization of cytoplasmic microtubules during interphase and mitosis. Meiosis and ascospore formation were not affected. Disruption of the kipB gene was synthetically lethal in combination with the temperature-sensitive mitotic kinesin motor mutation bimC4, suggesting an important but redundant role of KipB in mitosis. KipB localized to cytoplasmic, astral, and mitotic microtubules in a discontinuous pattern, and spots of green fluorescent protein moved along microtubules toward the plus ends.
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