ArticleBiophysical journal2004
The intermediate filament architecture as determined by X-ray diffraction modeling of hard alpha-keratin.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 71 citations in OpenAlex.
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- Pepsin Digestion for Proteomic Studies of the Human Hair Shaft.Rapid communications in mass spectrometry : RCM · 2026Article
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- A dynamic biointerface in mussels mediated by a mechanoresponsive intermediate filament-based biopolymer.Nature communications · 2025Article
- Keratin from Animal By-Products: Structure, Characterization, Extraction and Application-A Review.Polymers · 2024Review
- Strain and Strain Recovery of Human Hair from the Nano- to the Macroscale.Life (Basel, Switzerland) · 2023Article
- Integrative measurement analysis via machine learning descriptor selection for investigating physical properties of biopolymers in hairs.Scientific reports · 2021Article
- Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12.Nature structural & molecular biology · 2021Article
- Microbial enzymes catalyzing keratin degradation: Classification, structure, function.Biotechnology advances · 2020Review
- Porosity at Different Structural Levels in Human and Yak Belly Hair and Its Effect on Hair Dyeing.Molecules (Basel, Switzerland) · 2020Article
- Keratin Associations with Synthetic, Biosynthetic and Natural Polymers: An Extensive Review.Polymers · 2019Review
- Microbial Keratinases: Enzymes with Promising Biotechnological Applications.Food technology and biotechnology · 2018Review
- Multiscale modeling of keratin, collagen, elastin and related human diseases: Perspectives from atomistic to coarse-grained molecular dynamics simulations.Extreme Mechanics Letters · 2018Article
- Giant axonal neuropathy alters the structure of keratin intermediate filaments in human hair.Journal of the Royal Society, Interface · 2017Article
- Local structure of human hair spatially resolved by sub-micron X-ray beam.Scientific reports · 2015Article
- Effect of shampoo, conditioner and permanent waving on the molecular structure of human hair.PeerJ · 2015Article
- The structure of people's hair.PeerJ · 2014Article
- Keratinization and its disorders.Oman medical journal · 2012Article
- Structure and dynamics of human vimentin intermediate filament dimer and tetramer in explicit and implicit solvent models.Journal of molecular modeling · 2011Article
- The Molecular Architecture for the Intermediate Filaments of Hard α-Keratin Based on the Superlattice Data Obtained from a Study of Mammals Using Synchrotron Fibre Diffraction.Biochemistry research international · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite investigation since the 1950s, the molecular architecture of intermediate filaments has not yet been fully elucidated. Reliable information about the longitudinal organization of the molecules within the filaments and about the lateral interfilament packing is now available, which is not the case for the transverse architecture. Interesting results were recently obtained from in vitro microscopy observations and cross-linking of keratin, desmin, and vimentin analyses. The structural features that emerge from these analyses could not be fully representative of the in vivo architecture because intermediate filaments are subject to polymorphism. To bring new light to the transverse intermediate filament architecture, we have analyzed the x-ray scattering equatorial profile of human hair. Its comparison with simulated profiles from atomic models of a real sequence has allowed results to be obtained that are representative of hard alpha-keratin intermediate filaments under in vivo conditions. In short, the alpha-helical coiled coils, which are characteristic of the central rod of intermediate filament dimers, are straight and not supercoiled into oligomers; the radial density across the intermediate filament section is fairly uniform; the coiled coils are probably assembled into tetrameric oligomers, and finally the oligomer positions and orientations are not regularly ordered. These features are discussed in terms of filament self-assembling and structural variability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.