ArticleBiophysical journal2004
Revisiting voltage-dependent relief of block in ion channels: a mechanism independent of punchthrough.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Molecular Mechanisms of Nicergoline from Ergot Fungus in Blocking Human 5-HT3A Receptor.Journal of microbiology and biotechnology · 2024Article
- Asymmetric Interplay Between KFrontiers in physiology · 2021Article
- Exploring the Nature of Cationic Blocker Recognition by the Anthrax Toxin Channel.Biophysical journal · 2019Article
- Bases of Bacterial Sodium Channel Selectivity Among Organic Cations.Scientific reports · 2019Article
- cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.PloS one · 2014Article
- The voltage-dependent gate in MthK potassium channels is located at the selectivity filter.Nature structural & molecular biology · 2013Article
- Voltage-dependent gating in a "voltage sensor-less" ion channel.PLoS biology · 2010Article
- Closed-channel block of BK potassium channels by bbTBA requires partial activation.The Journal of general physiology · 2009Article
- Amphiphilic blockers punch through a mutant CLC-0 pore.The Journal of general physiology · 2009Article
- Blocking pore-open mutants of CLC-0 by amphiphilic blockers.The Journal of general physiology · 2009Article
- Properties of the inner pore region of TRPV1 channels revealed by block with quaternary ammoniums.The Journal of general physiology · 2008Article
- TRESK-like potassium channels in leukemic T cells.Pflugers Archiv : European journal of physiology · 2008Article
- The protonation state of the Glu-71/Asp-80 residues in the KcsA potassium channel: a first-principles QM/MM molecular dynamics study.Biophysical journal · 2007Article
- On the mechanism of TBA block of the TRPV1 channel.Biophysical journal · 2007Article
- Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites.The Journal of general physiology · 2005Article
- A cytosolic residue mediates Mg2+ block and regulates inward current amplitude of a transient receptor potential channel.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- New insights on the voltage dependence of the KCa3.1 channel block by internal TBA.The Journal of general physiology · 2004Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Voltage dependence of block was investigated in a simple model for permeation in a multiion pore. Internal blocker could bind to three states of the open channel that differed in the locations and number of permeant ion bound; blocker dissociation occurs exclusively to the internal solution, and the blocker does not itself enter the electric field. By changing the relative stability of blocker binding to these three states, block displayed voltage dependence with relief of block at high potentials. Similar patterns of block could also be generated in more detailed models of ion permeation. These results illustrate that the observation of relief of block at high potentials is not a sufficient criterion for establishing that a blocker is permeant in a channel that has a complex permeation cycle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.