Evidence map›Paper›PMID 15188496›Full record

ArticleWorld journal of gastroenterology2004

Cloning and identification of NS5ATP2 gene and its spliced variant transactivated by hepatitis C virus non-structural protein 5A.

Qian Yang, Jun Cheng, Yan Liu, Yuan Hong, Jian-Jun Wang, Shu-Lin Zhang

Abstract read
In one paragraph

Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. American journal of cancer research · 2024
    Article
  3. Roles of NOLC1 in cancers and viral infection.Journal of cancer research and clinical oncology · 2023
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qian YangDepartment of Infectious Diseases, First Hospital of Xi'an Jiaotong University, Shaanxi Province, China.
Jun Cheng
Yan Liu
Yuan Hong
Jian-Jun Wang
Shu-Lin Zhang

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo clone, identify and study new NS5ATP2 gene and its spliced variant transactivated by hepatitis C virus non-structural protein 5A.

methodsOn the basis of subtractive cDNA library of genes transactivated by NS5A protein of hepatitis C virus, the coding sequence of new gene and its spliced variant were obtained by bioinformatics method. Polymerase chain reaction (PCR) was conducted to amplify NS5ATP2 gene.

resultsThe coding sequence of a new gene and its spliced variant were cloned and identified successfully.

conclusionA new gene has been recognized as the new target transactivated by HCV NS5A protein. These results brought some new clues for studying the biological functions of new genes and pathogenesis of the viral proteins.

Indexed as

RNA SplicingAntigens, Polyomavirus TransformingBase SequenceCell Line, TumorCloning, MolecularGene Expression Regulation, ViralGene LibraryHepacivirusHepatoblastomaHumansLiver NeoplasmsMolecular Sequence DataPromoter Regions, GeneticRNA-Dependent RNA PolymeraseViral Nonstructural ProteinsAntigens, Polyomavirus TransformingNS-5 protein, hepatitis C virusRNA-Dependent RNA PolymeraseViral Nonstructural Proteins

Identifiers

PMID15188496
PMCPMC4572259

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.