ArticleJournal of immunology (Baltimore, Md. : 1950)2004
A two-step model of acute CD4 T-cell mediated cardiac allograft rejection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The number of donor HLA-derived T cell epitopes available for indirect antigen presentation determines the risk for vascular rejection after kidney transplantation.Frontiers in immunology · 2022Article
- Immunogenicity in Stem Cell Therapy for Cardiac Regeneration.Acta Cardiologica Sinica · 2020Review
- The Role of Major Histocompatibility Complex in Organ Transplantation- Donor Specific Anti-Major Histocompatibility Complex Antibodies Analysis Goes to the Next Stage.International journal of molecular sciences · 2019Review
- T cell Allorecognition Pathways in Solid Organ Transplantation.Frontiers in immunology · 2018Review
- Redox-Dependent Inflammation in Islet Transplantation Rejection.Frontiers in endocrinology · 2018Review
- Down-regulating cyclin-dependent kinase 9 of alloreactive CD4+ T cells prolongs allograft survival.Oncotarget · 2016Article
- Diversity of the CD4 T Cell Alloresponse: The Short and the Long of It.Cell reports · 2016Article
- Direct and indirect allograft recognition: pathways dictating graft rejection mechanisms.Current opinion in organ transplantation · 2016Review
- CD4 T cells mediate cardiac xenograft rejection via host MHC Class II.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2012Article
- Suppression of allograft rejection by Tim-1-Fc through cross-linking with a novel Tim-1 binding partner on T cells.PloS one · 2011Article
- Prolongation of cardiac allograft survival by a novel population of autologous CD117+ bone marrow-derived progenitor cells.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2011Article
- Acute cardiac allograft rejection by directly cytotoxic CD4 T cells: parallel requirements for Fas and perforin.Transplantation · 2010Article
- CD4+ T lymphocytes are not necessary for the acute rejection of vascularized mouse lung transplants.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Spontaneous allograft tolerance in B7-deficient mice independent of preexisting endogenous CD4+CD25+ regulatory T-cells.Transplantation · 2007Article
- Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus.The Journal of clinical investigation · 2007Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
CD4 T cells are both necessary and sufficient to mediate acute cardiac allograft rejection in mice. This process requires "direct" engagement of donor MHC class II molecules. That is, acute rejection by CD4+ T cells requires target MHC class II expression by the donor and not by the host. However, it is unclear whether CD4+ T cell rejection requires MHC class II expression on donor hemopoietic cells, nonhemopoietic cells, or both. To address this issue, bone marrow transplantation in mice was used to generate chimeric heart donors in which MHC class II was expressed either on somatic or on hemopoietic cells. We report that direct recognition of hemopoietic and nonhemopoietic cells are individually rate limiting for CD4+ T cell-mediated rejection in vivo. Importantly, active immunization with MHC class II(+) APCs triggered acute rejection of hearts expressing MHC class II only on the somatic compartment. Thus, donor somatic cells, including endothelial cells, are not sufficient to initiate acute rejection; but they are necessary as targets of direct alloreactive CD4 T cells. Taken together, results support a two-stage model in which donor passenger leukocytes are required to activate the CD4 response while direct interaction with the somatic compartment is necessary for the efferent phase of acute graft rejection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.