ArticleDigestive diseases and sciences2004
The importance of interleukin 18, glutathione peroxidase, and selenium concentration changes in acute pancreatitis.
Article in Digestive diseases and sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Systematic Review of Role of Oxidative Stress and Clinical Implications in Acute Pancreatitis.World journal of surgery · 2026Pooled it
- Antioxidant Upregulation Contributes to Improvements in Diaphragm Function Following Cervical Spinal Cord Injury and Hyperbaric Oxygen Therapy.Antioxidants (Basel, Switzerland) · 2026Article
- A lipid-immune network signature defines susceptibility to asparaginase-associated pancreatitis.JCI insight · 2026Article
- IL18 Works Like a Two-Side Coin in Acute Pancreatitis.International journal of general medicine · 2026Article
- Targeting Oxidative Stress in Acute Pancreatitis: A Critical Review of Antioxidant Strategies.Nutrients · 2025Review
- Interleukins: pathophysiological role in acute pancreatitis.Archives of medical science : AMS · 2024Article
- Fire in the belly: A scoping review of the immunopathological mechanisms of acute pancreatitis.Frontiers in immunology · 2022Article
- Downregulating Gasdermin D Reduces Severe Acute Pancreatitis Associated with Pyroptosis.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Prophylactic Administration of Silybin Ameliorates L-Arginine-Induced Acute Pancreatitis.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Interleukin 18 as an early marker or prognostic factor in acute pancreatitis.Przeglad gastroenterologiczny · 2015Article
- Role of Biomarkers in Diagnosis and Prognostic Evaluation of Acute Pancreatitis.Journal of biomarkers · 2015Review
- Protein alterations associated with pancreatic cancer and chronic pancreatitis found in human plasma using global quantitative proteomics profiling.Journal of proteome research · 2011Article
- Usefulness of assessing circulating levels of resistin, ghrelin, and IL-18 in alcoholic acute pancreatitis.Digestive diseases and sciences · 2010Article
- Infectious complications in patients with severe acute pancreatitis.Digestive diseases and sciences · 2009Article
- Serum selenium and glutathione peroxidase-3 activity: biomarkers of systemic inflammation in the critically ill?Intensive care medicine · 2009Article
- Severe acute pancreatitis: pathogenetic aspects and prognostic factors.World journal of gastroenterology · 2008Review
- Significant elevation of serum interleukin-18 levels in patients with acute pancreatitis.Journal of gastroenterology · 2006Article
- Significance of elevated serum IL-18 levels in patients with acute pancreatitis.Journal of gastroenterology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokinemia and oxidative stress are important factors responsible for an inadequate immune response in the early course of acute pancreatitis (AP). The aim of the study was to evaluate the profiles of interleukin 18 (IL-18), glutathione peroxidase (GPx), and selenium concentrations in serum with respect to AP severity and to study the relationships between these parameters and recognized prognostic indicators of AP severity. Prospective clinical analyses were performed on 61 patients with mild and severe forms of AP and for 15 healthy volunteers. In both forms of AP severity, the IL-18 concentration in the serum was significantly higher than in healthy controls. In the severe form of AP, the IL-18 concentration was the highest and exceeded significantly the values recorded on the 1st, 2nd, 3rd, 5th, and 10th days of mild AP. A significantly lower GPx concentration in the serum was recorded in severe AP compared to the mild form and in the control group. There was a significantly lower selenium concentration in the severe form of AP. Significant correlations between GPx and selenium, between IL-18 and GPx, and between IL-18 and selenium were recorded. The ROC analysis shows a high prognostic accuracy of IL-18 and GPx concentrations in the determination of AP severity. IL-18 is released early in the course of AP and may be a key immunomodulator of the inflammatory response in the severe form of this disease. Low GPx and selenium concentrations in severe AP reflect the lower antioxidative ability in this form of AP. IL-18 and GPx may represent new indicators of AP severity.
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