ArticleDigestive diseases and sciences2004
Impact of dextran sulfate sodium load on the severity of inflammation in experimental colitis.
Article in Digestive diseases and sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
65 citing papers in PubMed.
- Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Toll-like Receptor 9 Mediates Epstein-Barr Virus-Aggravated Inflammation in a Mouse Model of Inflammatory Bowel Disease.Biomedicines · 2025Article
- Erlotinib suppresses tumorigenesis in a mouse model of colitis-associated cancer.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024Article
- The Effects of Endosomal Toll-like Receptor Inhibitors in an EBV DNA-Exacerbated Inflammatory Bowel Disease Mouse Model.Viruses · 2024Article
- Daikenchuto, a Japanese herbal medicine, ameliorates experimental colitis in a murine model by inducing secretory leukocyte protease inhibitor and modulating the gut microbiota.Frontiers in immunology · 2024Article
- Severity Classification of Laboratory Animal Procedures in Two Belgian Academic Institutions.Animals : an open access journal from MDPI · 2023Article
- Effect of Clostridium butyricum on High-Fat Diet-Induced Intestinal Inflammation and Production of Short-Chain Fatty Acids.Digestive diseases and sciences · 2023Article
- Protective effects of amoxicillin and probiotics on colon disorders in an experimental model of acute diverticulitis disease.Inflammopharmacology · 2022Article
- Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop.Cell death & disease · 2022Article
- Irisin attenuates inflammation in a mouse model of ulcerative colitis by altering the intestinal microbiota.Experimental and therapeutic medicine · 2021Article
- Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model.Journal of visualized experiments : JoVE · 2021Article
- The nitroxide 4-methoxy-tempo inhibits the pathogenesis of dextran sodium sulfate-stimulated experimental colitis.Redox biology · 2020Article
- A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice.Nature communications · 2019Article
- Protective Effects of Protegrin in Dextran Sodium Sulfate-Induced Murine Colitis.Frontiers in pharmacology · 2019Article
- The Bisindole Alkaloid Caulerpin, from Seaweeds of the GenusMarine drugs · 2018Article
- Mucus models to evaluate the diffusion of drugs and particles.Advanced drug delivery reviews · 2018Review
- Microbial Changes and Host Response in F344 Rat Colon Depending on Sex and Age Following a High-Fat Diet.Frontiers in microbiology · 2018Article
- Chemically induced mouse models of acute and chronic intestinal inflammation.Nature protocols · 2017Article
- Prevent Effects of Lactobacillus Fermentum HY01 on Dextran Sulfate Sodium-Induced Colitis in Mice.Nutrients · 2017Article
- Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
In dextran sulfate sodium (DSS)-induced inflammatory bowel disease in mice the relationship between the amount of ingested DSS and the severity of colitis has not been systematically investigated. We examined whether (1) the severity of colitis is DSS load-dependent, and (2) there is a critical DSS load required to reliably induce colitis. DSS load was calculated as: (drinking volume (ml) x [DSS (g)/100 ml])/body weight (g). A minimum DSS load > or = 30 mg/g body weight over 7 days resulted in a significantly elevated colonic myeloperoxidase (MPO) activity, compared to mice receiving less DSS and controls (P < 0.05). Histomorphologic data correlated with MPO activity and revealed significantly higher damage scores once the DSS load was > or = 30 mg/g body weight. Our findings demonstrate the importance of monitoring DSS load in this model of experimental colitis.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.