ArticleProceedings of the National Academy of Sciences of the United States of America2004
Silencing of a gene adjacent to the breakpoint of a widespread Drosophila inversion by a transposon-induced antisense RNA.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 81 citations in OpenAlex.
- Genomic Landscape of High-Altitude Adaptation in East African Mountain Honey Bees (Ecology and evolution · 2025Article
- Chromosomal inversions and their impact on insect evolution.Current opinion in insect science · 2024Review
- Genomics of natural populations: gene conversion events reveal selected genes within the inversions of Drosophila pseudoobscura.G3 (Bethesda, Md.) · 2024Article
- Long-Term Maintenance of Complex Chromosomal Inversion Polymorphism inEcology and evolution · 2024Article
- Contrasting Patterns of Single Nucleotide Polymorphisms and Structural Variation Across Multiple Invasions.Molecular biology and evolution · 2023Article
- The relevance of chromatin architecture to genome rearrangements inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Fine-Scale Position Effects Shape the Distribution of Inversion Breakpoints in Drosophila melanogaster.Genome biology and evolution · 2020Article
- Basal hsp70 expression levels do not explain adaptive variation of the warm- and cold-climate OBMC evolutionary biology · 2020Article
- The evolutionary arms race between transposable elements and piRNAs in Drosophila melanogaster.BMC evolutionary biology · 2020Article
- Article
- The Genomic Complexity of a Large Inversion in Great Tits.Genome biology and evolution · 2019Article
- How chromosomal rearrangements shape adaptation and speciation: Case studies in Drosophila pseudoobscura and its sibling species Drosophila persimilis.Molecular ecology · 2019Article
- The molecular characterization of fixed inversions breakpoints unveils the ancestral character of the Drosophila guanche chromosomal arrangements.Scientific reports · 2019Article
- Article
- Origin and Consequences of Chromosomal Inversions in the virilis Group of Drosophila.Genome biology and evolution · 2018Article
- Systems genetic analysis of inversion polymorphisms in the malaria mosquitoProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Multiple large inversions and breakpoint rewiring of gene expression in the evolution of the fire ant social supergene.Proceedings. Biological sciences · 2018Article
- Inversion evolutionary rates might limit the experimental identification of inversion breakpoints in non-model species.Scientific reports · 2017Article
- Silencing of Transposable Elements by piRNAs in Drosophila: An Evolutionary Perspective.Genomics, proteomics & bioinformatics · 2017Review
- Chromosome inversions and ecological plasticity in the main African malaria mosquitoes.Evolution; international journal of organic evolution · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adaptive changes in nature occur by a variety of mechanisms, and Drosophila chromosomal inversions was one of the first studied examples. However, the precise genetic causes of the adaptive value of inversions remain uncertain. Here we investigate the impact of the widespread inversion 2j of Drosophila buzzatii on the expression of the CG13617 gene, whose coding region is located only 12 bp away from the inversion proximal breakpoint. This gene is transcribed into a 2.3-kb mRNA present in all D. buzzatii developmental stages. More importantly, the expression level of CG13617 is reduced 5-fold in embryos of lines homozygous for the 2j inversion compared with lines without the inversion. An antisense RNA that originates in the Foldback-like transposon Kepler inserted at the breakpoint junction in all of the 2j lines and that forms duplexes with the CG13617 mRNA in 2j embryos is most likely responsible for the near silencing of the gene. Few examples of RNA interference caused by transposable elements (TEs) have been previously described, but this mechanism might be prevalent in many organisms and illustrates the potential of TEs as a major source of genetic variation. In addition, because chromosomal rearrangements are usually induced by TEs, position effects might be more common than previously recognized and contribute significantly to the evolutionary success of inversions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.