ArticleJournal of clinical microbiology2004
Hepatitis B virus genotypes and precore and core mutants in Brazilian patients.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 137 citations in OpenAlex.
- Prevalence and genotypes distribution of virus hepatitis B and hepatitis delta virus in chronic liver diseases in Kazakhstan.BMC infectious diseases · 2023Trial
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- Hepatitis A, B and C prevalence among transgender women and travestis in five Brazilian capitals between 2019-2021.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2024Article
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- Hepatitis B Prevalence among Men Who Have Sex with Men in Brazil.Tropical medicine and infectious disease · 2023Article
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- Molecular evaluation of hepatitis B virus infection and predominant mutations of pre-core, basal core promoter and S regions in an Iranian population with type 2 diabetes mellitus: a case-control study.BMC infectious diseases · 2022Article
- Frequency of Hepatitis B Markers in Systemic Lupus Erythematosus Patients in Iran.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Whole genome analysis of hepatitis B virus before and during long-term therapy in chronic infected patients: Molecular characterization, impact on treatment and liver disease progression.Frontiers in microbiology · 2022Article
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- Hepatitis B virus genotypes prevalence in patients from hepatology services in Ceará, Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2021Article
- Hepatitis B in the Northwestern region of Sao Paulo State: genotypes and resistance mutations.Revista do Instituto de Medicina Tropical de Sao Paulo · 2021Article
- Frequency of OBI among Patients with Autoimmune Hepatitis.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Massive Iatrogenic Outbreak of Human Immunodeficiency Virus Type 1 in Rural Cambodia, 2014-2015.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Nationwide overview of the distribution of hepatitis B virus genotypes in Brazil: a 1000-sample multicentre study.The Journal of general virology · 2017Article
- Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B.Infection and drug resistance · 2017Article
- Exposition of hepatitis B surface antigen (HBsAg) on the surface of HEK293T cell and evaluation of its expression.Research in pharmaceutical sciences · 2016Article
- Genotyping and Mutation Pattern in the Overlapping MHR Region of HBV Isolates in Southern Khorasan, Eastern Iran.Hepatitis monthly · 2016Article
- Study of the Association of Mutant HBsAg Gene and Hodgkin and Non-Hodgkin Lymphoma.Jundishapur journal of microbiology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A method for genotyping hepatitis B virus by partial HBsAg gene sequencing with primers common to all known genotypes was developed. Mutations related to anti-HBs resistance are also detected with this method. Samples from 103 Brazilian patients were analyzed. Precore and core region of these viruses were also sequenced in 101 patients. Genotypes A, B, C, D, and F were found with frequencies of 49.5, 2.9, 13.6, 24.3, and 9.7%, respectively. Genotypes B and C were found only in Asian patients, whereas genotypes A, D, and F were more common in patients without an Asian background. Precore mutants were found in 32 (31.7%) of 101 patients, with a higher frequency in those infected with genotype D (22 of 25 [88.0%]). Analysis of nucleotide 1858 showed presence of thymine in all patients with genotypes B, C, and D and in a few patients with genotypes A (10.0%) and F (30.0%), who showed more frequently the presence of cytosine. This nucleotide was closely related to the presence of precore mutants. Mutations in the basal core promoter were found in 64 of 101 (63.4%) samples. These mutations were more frequent in patients infected with genotype F (90.0%) and less frequent in patients infected with genotype B (33.3%). Deletions in this region were found in two genotype C-infected patients.
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