ArticleCancer science2004
Expression of the prolactin-inducible protein (PIP/GCDFP15) gene in benign epithelium and adenocarcinoma of the prostate.
Article in Cancer science, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- TRPS1 expression in cytokeratin 5 expressing triple negative breast cancers, its value as a marker of breast origin.Virchows Archiv : an international journal of pathology · 2023Article
- MiR-155, a potential serum marker of extramammary Paget's disease.BMC cancer · 2018Article
- Prolactin-induced protein (PIP)-characterization and role in breast cancer progression.American journal of cancer research · 2018Review
- Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases.Journal of translational medicine · 2015Review
- Reciprocity in the developmental regulation of aquaporins 1, 3 and 5 during pregnancy and lactation in the rat.PloS one · 2014Article
- Low serum testosterone levels are predictive of prostate cancer.World journal of urology · 2013Article
- Emerging roles of human prostatic Acid phosphatase.Biomolecules & therapeutics · 2013Review
- Runx2 controls a feed-forward loop between androgen and prolactin-induced protein (PIP) in stimulating T47D cell proliferation.Journal of cellular physiology · 2012Article
- Co-purification of Mac-2 binding protein with galectin-3 and association with prostasomes in human semen.The Prostate · 2011Article
- Augmentation of 3-methylcholanthrene-induced bioactivation in the human hepatoma cell line HepG2 by the calcium channel blocker nicardipine.Cancer science · 2010Article
- Regulation of clustered gene expression by cofactor of BRCA1 (COBRA1) in breast cancer cells.Oncogene · 2007Article
- Gene expression studies in prostate cancer tissue: which reference gene should be selected for normalization?Journal of molecular medicine (Berlin, Germany) · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prolactin-inducible protein (PIP), also known as gross cystic disease fluid protein 15, is a predominant secretory protein in various body fluids, including saliva, milk and seminal plasma. Immunohistochemistry of this protein has been exploited as a clinical marker for breast cancer and Paget's disease. This study comparatively examined PIP expression in normal prostate tissues and in adenocarcinomas of the prostate. Quantitative real-time RT-PCR revealed low-level presence (6%) of PIP mRNA in normal prostate tissue in comparison with the seminal vesicle. Indirect immunostaining with monoclonal antibody 3E7 displayed a positive sign for benign epithelium in 8 cases (29.6%) among 27 normal specimens; however, the incidence significantly increased to 56.1% (37/66) in instances involving primary prostate carcinoma tissues of different types. Quantitative RT-PCR also demonstrated that PIP transcript levels in carcinoma regions were significantly higher than corresponding levels in benign regions. These findings conclusively showed that benign prostate epithelium expresses PIP at low levels; in contrast, PIP is over-expressed in carcinomas of the prostate.
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