ArticleBMC psychiatry2004
No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study.
Article in BMC psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies.Journal of psychiatry & neuroscience : JPN · 2009Pooled it
- Perspectives from the Society for Pediatric Research: pharmacogenetics for pediatricians.Pediatric research · 2022Review
- Pharmacogenomic Testing in Child and Adolescent Psychiatry: An Evidence-Based Review.Current problems in pediatric and adolescent health care · 2018Review
- Influence of the COMT val(108/158)met polymorphism on continuous performance task indices.Neuropsychologia · 2014Article
- Count on dopamine: influences of COMT polymorphisms on numerical cognition.Frontiers in psychology · 2013Article
- Association between the Catechol O-methyltransferase (COMT) Val158met polymorphism and different dimensions of impulsivity.PloS one · 2013Article
- The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD.Behavioral and brain functions : BBF · 2012Article
- Neuropsychological endophenotypes in attention-deficit/hyperactivity disorder: a review of genetic association studies.European archives of psychiatry and clinical neuroscience · 2011Review
- Neurobehavioral evidence for changes in dopamine system activity during adolescence.Neuroscience and biobehavioral reviews · 2010Review
- A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Article
- Catechol-O-methyltransferase and its inhibitors in Parkinson's disease.CNS drug reviews · 2007Review
- Catechol-O-methyltransferase (COMT) Val108/158 Met polymorphism does not modulate executive function in children with ADHD.BMC medical genetics · 2004Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundSeveral studies have suggested an association between the functional Val158Met polymorphism in the Catechol-O-Methyltransferase (COMT) gene and neurocognitive performance. Two studies showed that subjects with the low activity Met allele performed better on the Wisconsin Card Sorting Test (WCST) and another study found an effect on processing speed and attention.
methodsWe set out to examine the association between the Val158Met polymorphism and performance on neurocognitive tasks including those tapping working memory, attention and speed, impulsiveness and response inhibition in a sample of 124 children with ADHD. Task performance for each genotypic group was compared using analysis of variance.
resultsThere was no evidence of association with performance on any of the neurocognitive tasks.
conclusionsWe conclude that Val158Met COMT genotype is not associated with neurocognitive performance in our sample.
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