ArticleMammalian genome : official journal of the International Mammalian Genome Society2004
Genetic complexity of an obesity QTL ( Fob3) revealed by detailed genetic mapping.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- DEPTOR at the Nexus of Cancer, Metabolism, and Immunity.Physiological reviews · 2018Review
- Review
- Fine-mapping QTLs in advanced intercross lines and other outbred populations.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Association studies in outbred mice in a new era of full-genome sequencing.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.Cell metabolism · 2012Article
- Forward genetic approaches to understanding complex behaviors.Current topics in behavioral neurosciences · 2012Review
- Obesity resistant mechanisms in the Lean polygenic mouse model as indicated by liver transcriptome and expression of selected genes in skeletal muscle.BMC genomics · 2011Article
- Mapping quantitative traits and strategies to find quantitative trait genes.Methods (San Diego, Calif.) · 2011Review
- Nonalcoholic Fatty liver disease: focus on lipoprotein and lipid deregulation.Journal of lipids · 2011Article
- A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies novel candidate obesity genes.PloS one · 2011Article
- Congenic and bioinformatics analyses resolved a major-effect Fob3b QTL on mouse Chr 15 into two closely linked loci.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Genetic architecture of quantitative traits in mice, flies, and humans.Genome research · 2009Article
- A growth QTL (Pbwg1) region of mouse chromosome 2 contains closely linked loci affecting growth and body composition.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Fine mapping dissects pleiotropic growth quantitative trait locus into linked loci.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Mapping of the Plasmodium chabaudi resistance locus char2.Infection and immunity · 2006Article
- Article
- Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains.BMC genomics · 2006Article
- Finding the molecular basis of complex genetic variation in humans and mice.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Review
- Selection in backcross programmes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
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7 authors.
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Abstract
Obesity is proving to be a serious health concern in the developed world as well as an unwanted component of growth in livestock production. While recent advances in genetics have identified a number of monogenic causes of obesity, these are responsible for only a small proportion of human cases of obesity. By divergent selection for high and low fat content over 60 generations, we have created Fat (F) and Lean (L) lines of mice that represent a model of polygenic obesity similar to the situation in human populations. From previous crosses of these lines, four body fat quantitative trait loci (QTL) were identified. We have created congenic lines (F(chr15L)), by recurrent marker-assisted backcrossing, to introgress the QTL region with the highest LOD score, Fob3 on Chr 15, from the L-Iine into the F-line background. We have further mapped this QTL by progeny testing of recombinants, produced from crosses between the F-line and congenic F(chrl5L) mice, showing that the Fob3 QTL region is a composite of at least two smaller effect QTL-the proximal QTL Fob3a is a late-onset obesity QTL, whereas the distal Fob3b is an early-onset obesity QTL.
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