ArticleMammalian genome : official journal of the International Mammalian Genome Society2004
Mouse testis transcriptome revealed using serial analysis of gene expression.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Article
- Article
- Effects of melatonin on testicular function in adult male mice under different photoperiods.Animal reproduction · 2022Article
- Article
- The role of Dby mRNA in early development of male mouse zygotes.Asian journal of andrology · 2010Article
- Testicular postgenomics: targeting the regulation of spermatogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Identification of differentially expressed genes in senescence-accelerated mouse testes by suppression subtractive hybridization analysis.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Global transcriptome analysis of the C57BL/6J mouse testis by SAGE: evidence for nonrandom gene order.BMC genomics · 2005Article
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Authors and funding
9 authors.
Funding
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Abstract
We applied serial analysis of gene expression (SAGE) to the mouse testis to reveal the global gene expression profile and to identify senescence-dependent changes in that profile. A total of 61,929 SAGE tags, including 19,323 unique tags, were obtained from 3- and 29-month-old BDF1 mice and 14-month-old SAMP1 mice. Genes highly expressed in the testis included those associated with spermatogenesis, protein metabolism, energy metabolism, growth and differentiation, and signal transduction. Testes from old mice of both strains appeared atrophied. Morphological examination of aged testes revealed extremely thin seminiferous epithelia and significantly decreased numbers of spermatids and spermatocytes. Despite the physical deterioration, no gross changes in the gene expression profile were apparent in the testes of old BDF1 mice. However, in 14-month-old SAMP1 mice, protamine 2 gene transcription was approximately 50% lower than in BDF1 mice. This reduction may be associated with the oligozoospermia and early decline in reproductive performance of SAMP1 mice. Our SAGE results are the first quantitative gene expression profile of the mouse testis and provide a reliable transcriptome reference for this organ.
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