ReviewImmunologic research2004
Transcriptional control of thymocyte positive selection.
Review in Immunologic research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 7 citations in OpenAlex.
- Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis.The Journal of experimental medicine · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thymocyte development proceeds through multiple regulated checkpoints to ensure that the mature T-cell population is useful for recognition of self major histocompatibility complex (MHC) molecules, but not overtly autoreactive. Developing cells pass the positive selection checkpoint when the T-cell receptor (TCR) on immature thymocytes engages self peptide/MHC with low affinity. The resulting signal transduction initiates migration, survival, maturation, allelic exclusion, and lineage commitment. The changes in gene expression necessary for all of these cellular events are controlled by transcription factors responsive to signals in immature thymocytes. Recent progress has defined a small group of transcription factors that can be clearly linked to regulation of gene expression during positive selection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.