ArticleNucleic acids research2004
The Drosophila Bruno paralogue Bru-3 specifically binds the EDEN translational repression element.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Bruno-3 regulates sarcomere component expression and contributes to muscle phenotypes of myotonic dystrophy type 1.Disease models & mechanisms · 2018Article
- CUG-BP, Elav-like family member 1 (CELF1) is required for normal myofibrillogenesis, morphogenesis, and contractile function in the embryonic heart.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Extending the dynamic range of transcription factor action by translational regulation.Physical review. E · 2016Article
- Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF1.Nucleic acids research · 2013Article
- Sequence determinants for the tandem recognition of UGU and CUG rich RNA elements by the two N--terminal RRMs of CELF1.Nucleic acids research · 2011Article
- Coordinate regulation of mRNA decay networks by GU-rich elements and CELF1.Current opinion in genetics & development · 2011Review
- Bruno protein contains an expanded RNA recognition motif.Biochemistry · 2009Article
- Large introns in relation to alternative splicing and gene evolution: a case study of Drosophila bruno-3.BMC genetics · 2009Article
- Alternative splicing of NURF301 generates distinct NURF chromatin remodeling complexes with altered modified histone binding specificities.PLoS genetics · 2009Article
- A misexpression screen to identify regulators of Drosophila larval hemocyte development.Genetics · 2008Article
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- Repeat length and RNA expression level are not primary determinants in CUG expansion toxicity in Drosophila models.PloS one · 2008Article
- CUG-BP1/CELF1 requires UGU-rich sequences for high-affinity binding.The Biochemical journal · 2006Article
- Identification of CELF splicing activation and repression domains in vivo.Nucleic acids research · 2005Article
- A computational and experimental approach toward a priori identification of alternatively spliced exons.RNA (New York, N.Y.) · 2004Article
- CELFish ways to modulate mRNA decay.Biochimica et biophysica actaReview
- The importance of CELF control: molecular and biological roles of the CUG-BP, Elav-like family of RNA-binding proteins.Wiley interdisciplinary reviews. RNAReview
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7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We reported in our previous work that the EDEN-dependent translational repression of maternal mRNAs was conserved between Drosophila and Xenopus. In Xenopus, this repression is achieved through the binding of EDEN to the Bruno-like factor, EDEN-BP. We show in the present work that the Drosophila Bruno paralogue, the 45 kDa Bru-3 protein (p45), binds specifically to the EDEN element and acts as a homodimer. We describe for the first time a previously undetected 67 amino acid domain, found in the divergent linker region, the lsm domain (lsm stands for linker-specific motif). We propose that the presence of this domain in a subset of the Bruno-like proteins, including Bru-3, EDEN-BP and CUG-BP but not Bruno nor its other paralogue Bru-2, might be responsible for specific RNA recognition. Interestingly, comparative structural analyses using threaders and molecular modelling suggest that the new domain might be distantly related to the first RNA recognition motif of the Drosophila sex-lethal protein (sxl). The phylogenetic analyses and the experimental data based on its specific binding to the EDEN element support the conclusion that Bru-3 is an EDEN-BP/CUG-BP orthologue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.