ArticleThe Journal of physiology2004
Altered neurotransmitter control of reflex vasoconstriction in aged human skin.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The trial behind it
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Who cites it
41 citing papers in PubMed, 98 citations in OpenAlex.
- Oral sapropterin augments reflex vasoconstriction in aged human skin through noradrenergic mechanisms.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Trial
- Skin aging: mechanisms, evaluation, and rejuvenation.The EMBO journal · 2026Review
- Resting Body Temperature and Long-Term Survival in Older Adults at a Mental Health Center: Cross-Sectional and Longitudinal Data.Journal of clinical medicine · 2025Article
- Optimizing whole-body cryostimulation exposure duration: Effects of age, sex, and body mass index in achieving target skin temperature.Temperature (Austin, Tex.) · 2025Article
- Microvascular endothelial dysfunction in vascular senescence and disease.Frontiers in cardiovascular medicine · 2025Review
- Preterm-born individuals: a vulnerable population at risk of cardiovascular morbidity and mortality during thermal extremes?Experimental physiology · 2023Review
- Human vulnerability and variability in the cold: Establishing individual risks for cold weather injuries.Temperature (Austin, Tex.) · 2022Review
- Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology.Frontiers in endocrinology · 2022Review
- Influences of ovarian hormones on physiological responses to cold in women.Temperature (Austin, Tex.) · 2022Review
- Endothelial function is impaired in the cutaneous microcirculation of adults with psoriasis through reductions in nitric oxide-dependent vasodilation.American journal of physiology. Heart and circulatory physiology · 2018Article
- Sympathetic function during whole body cooling is altered in hypertensive adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Edward F. Adolph Distinguished Lecture: Skin-deep insights into vascular aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
- Neurovascular mechanisms underlying augmented cold-induced reflex cutaneous vasoconstriction in human hypertension.The Journal of physiology · 2017Article
- Sympathetic regulation during thermal stress in human aging and disease.Autonomic neuroscience : basic & clinical · 2016Review
- Nonthermal sensory input and altered human thermoregulation: effects of visual information depicting hot or cold environments.International journal of biometeorology · 2015Article
- Sympathetic control of reflex cutaneous vasoconstriction in human aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Review
- Purinergic signalling during development and ageing.Purinergic signalling · 2015Review
- The effect of aging on the cutaneous microvasculature.Microvascular research · 2015Review
- Impaired increases in skin sympathetic nerve activity contribute to age-related decrements in reflex cutaneous vasoconstriction.The Journal of physiology · 2015Article
- Lack of limb or sex differences in the cutaneous vascular responses to exogenous norepinephrine.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cutaneous vasoconstriction (VC) in response to cooling is attenuated in older humans; however, mechanisms underlying this functional decline remain unclear. The present study tested the hypothesis that the contributions of noradrenaline (NA) and sympathetic cotransmitters to reflex-mediated cutaneous VC are altered with age. In 11 young (18-26 years) and 11 older (61-77 years) men and women, forearm skin blood flow was monitored at three sites using laser Doppler flowmetry (LDF) while mean skin temperature was lowered from 34 to 30.5 degrees C using a water-perfused suit. Cutaneous vascular conductance (CVC; LDF/mean arterial pressure) was expressed as percentage change from baseline (% DeltaCVC(base)). Solutions of yohimbine + propranolol (Y + P), bretylium tosylate (BT), and lactated Ringer solution were infused via intradermal microdialysis at each LDF site to antagonize alpha- and beta-adrenoceptors, block sympathetic release of NA and cotransmitters, and act as control, respectively. During cooling, VC was attenuated at the control site in older subjects compared to young subjects (-16 +/- 3 versus-34 +/- 4% DeltaCVC(base), P < 0.001). Y + P attenuated VC in young subjects (-13 +/- 8% DeltaCVC(base), P < 0.001 versus control) and abolished VC in older subjects (0 +/- 3% DeltaCVC(base), P > 0.9 versus baseline). BT completely blocked VC in both age groups. Cutaneous VC in young subjects is mediated by both NA and sympathetic cotransmitter(s); however, reflex VC in aged skin is attenuated compared to young and appears to be mediated solely by NA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.