ArticleProceedings of the National Academy of Sciences of the United States of America2004
Age-structured red blood cell susceptibility and the dynamics of malaria infections.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and risk factors related to poor outcome of patients with severe Plasmodium vivax infection: a systematic review, meta-analysis, and analysis of case reports.BMC infectious diseases · 2020Pooled it
- Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum.Nature communications · 2014Trial
- Porin A and α/β-hydrolase are necessary and sufficient for hemolysis induced by Bartonella bacilliformis.Nature communications · 2025Article
- Review
- Knobs, Adhesion, and Severe Falciparum Malaria.Tropical medicine and infectious disease · 2023Review
- Infection age as a predictor of epidemiological metrics for malaria.Malaria journal · 2022Article
- Generation of red blood cells from stem cells: Achievements, opportunities and perspectives for malaria research.Frontiers in cellular and infection microbiology · 2022Review
- CD47 blockade reduces the pathologic features of experimental cerebral malaria and promotes survival of hosts withProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Accounting for red blood cell accessibility reveals distinct invasion strategies in Plasmodium falciparum strains.PLoS computational biology · 2020Article
- Recombinant vector vaccine evolution.PLoS computational biology · 2019Article
- Analysis of erythrocyte dynamics in Rhesus macaque monkeys during infection with Plasmodium cynomolgi.Malaria journal · 2018Article
- Investigating the Efficacy of Triple Artemisinin-Based Combination Therapies for Treating Plasmodium falciparum Malaria Patients Using Mathematical Modeling.Antimicrobial agents and chemotherapy · 2018Article
- Co-occurrence among three divergent plant-castrating fungi in the same Silene host species.Molecular ecology · 2018Article
- Examining the Reticulocyte Preference of TwoFrontiers in microbiology · 2018Article
- What Controls the Acute Viral Infection Following Yellow Fever Vaccination?Bulletin of mathematical biology · 2018Article
- The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites.PloS one · 2017Article
- Article
- Malaria in cynomolgus monkeys used in toxicity studies in Japan.Journal of toxicologic pathology · 2016Article
- Comparison of mathematical frameworks for modeling erythropoiesis in the context of malaria infection.Mathematical biosciences · 2015Article
- Exchange transfusion in complicated pediatric malaria: A critical appraisal.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2015Review
Corrections and comments
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2 authors.
Funding
Abstract
Malaria parasites and immune responses in an infected human interact on a dynamic landscape, in which a population of replicating parasites depletes a population of replenishing red blood cells (RBCs). These underlying dynamics receive relatively little attention, but they offer unique insights into the processes that control most malaria infections. Here, we focus on the observation that three of the four malaria-parasite species that infect humans are restricted to particular age classes of RBC. We explicitly incorporate this observation in models of infection dynamics to distinguish common from species-specific pressures on host immune responses, and we find that age structuring has profound effects on the course of infection. For all four species conditions exist under which the parasites may persist at low densities, or may clear, even in the absence of an immune response. Catastrophic anemia can occur even with the two species that attack only the youngest RBCs, although only a small fraction of cells are parasitized at any point. Furthermore, with these two, compensatory erythropoetic responses in the host accelerate parasite population growth. A "basic reproduction rate" characterizes these differences in outcomes.
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