ArticleProceedings of the National Academy of Sciences of the United States of America2004
Manipulation of light signal transduction as a means of modifying fruit nutritional quality in tomato.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers.
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Who cites it
148 citing papers in PubMed, 463 citations in OpenAlex.
- Loss of DET1 in High Pigment 2 Tomato Prevents High Temperature Repression of Anthocyanin Biosynthesis in Fruit Through HY5 Stabilization.Plant, cell & environment · 2026Article
- Manipulation of artificial light environment improves plant biomass and fruit nutritional quality in tomato.Journal of advanced research · 2025Article
- OptimizingPlants (Basel, Switzerland) · 2025Article
- Manipulating the Light Systemic Signal HY5 Greatly Improve Fruit Quality in Tomato.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Molecular breeding of tomato: Advances and challenges.Journal of integrative plant biology · 2025Review
- Determining the function of ripening associated genes and biochemical changes during tomato (Solanum lycopersicum L.) fruit maturation.Biotechnology letters · 2025Article
- Carotenoids in Potato Tubers: A Bright Yellow Future Ahead.Plants (Basel, Switzerland) · 2025Review
- Light-mediated activation ofFrontiers in plant science · 2025Article
- The resistance ofPhotosynthetica · 2025Article
- E3 ligase SlCOP1-1 stabilizes transcription factor SlOpaque2 and enhances fruit resistance to Botrytis cinerea in tomato.Plant physiology · 2024Article
- How Histone Acetyltransferases Shape Plant Photomorphogenesis and UV Response.International journal of molecular sciences · 2024Review
- A tomato NAC transcription factor, SlNAP1, directly regulates gibberellin-dependent fruit ripening.Cellular & molecular biology letters · 2024Article
- The growth, nutrient uptake and fruit quality in four strawberry cultivars under different Spectra of LED supplemental light.BMC plant biology · 2024Article
- UV RESISTANCE LOCUS 8-Mediated UV-B Response Is Required Alongside CRYPTOCHROME 1 for Plant Survival in Sunlight under Field Conditions.Plant & cell physiology · 2024Article
- Article
- Light regulation of the biosynthesis of phenolics, terpenoids, and alkaloids in plants.Communications biology · 2023Review
- Marker assisted early generation identification of root knot disease resistant orange tomato segregants with multiple desirable alleles.Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- HY5 functions as a systemic signal by integrating BRC1-dependent hormone signaling in tomato bud outgrowth.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genetic mapping of a single nuclear locus determines the white flesh color in watermelon (Frontiers in plant science · 2023Article
- Transcriptomic Analysis Suggests a Coordinated Regulation of Carotenoid Metabolism in Ripening Chili Pepper (Antioxidants (Basel, Switzerland) · 2022Article
88 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fruit constitutes a major component of human diets, providing fiber, vitamins, and phytonutrients. Carotenoids are a major class of compounds found in many fruits, providing nutritional benefits as precursors to essential vitamins and as antioxidants. Although recent gene isolation efforts and metabolic engineering have primarily targeted genes involved in carotenoid biosynthesis, factors that regulate flux through the carotenoid pathway remain largely unknown. Characterization of the tomato high-pigment mutations (hp1 and hp2) suggests the manipulation of light signal transduction machinery may be an effective approach toward practical manipulation of plant carotenoids. We demonstrate here that hp1 alleles represent mutations in a tomato UV-DAMAGED DNA-BINDING PROTEIN 1 (DDB1) homolog. We further demonstrate that two tomato light signal transduction genes, LeHY5 and LeCOP1LIKE, are positive and negative regulators of fruit pigmentation, respectively. Down-regulated LeHY5 plants exhibit defects in light responses, including inhibited seedling photomorphogenesis, loss of thylakoid organization, and reduced carotenoid accumulation. In contrast, repression of LeCOP1LIKE expression results in plants with exaggerated photomorphogenesis, dark green leaves, and elevated fruit carotenoid levels. These results suggest genes encoding components of light signal transduction machinery also influence fruit pigmentation and represent genetic tools for manipulation of fruit quality and nutritional value.
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