ReviewNeurochemical research2004
A molecular description of brain trauma pathophysiology using microarray technology: an overview.
Review in Neurochemical research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Research progress on biomarkers of traumatic brain injury.Animal models and experimental medicine · 2026Review
- Bioinformatics Analysis of miRNAs and mRNAs Network-Xuefu Zhuyu Decoction Exerts Neuroprotection of Traumatic Brain Injury Mice in the Subacute Phase.Frontiers in pharmacology · 2022Article
- MicroRNAs: The New Challenge for Traumatic Brain Injury Diagnosis.Current neuropharmacology · 2020Review
- Microglia Responses in Acute and Chronic Neurological Diseases: What Microglia-Specific Transcriptomic Studies Taught (and did Not Teach) Us.Frontiers in aging neuroscience · 2017Review
- Temporal Changes in Cortical and Hippocampal Expression of Genes Important for Brain Glucose Metabolism Following Controlled Cortical Impact Injury in Mice.Frontiers in endocrinology · 2017Article
- Smartphone-enabled optofluidic exosome diagnostic for concussion recovery.Scientific reports · 2016Article
- Epigenetic changes following traumatic brain injury and their implications for outcome, recovery and therapy.Neuroscience letters · 2016Review
- JNK3 involvement in nerve cell apoptosis and neurofunctional recovery after traumatic brain injury.Neural regeneration research · 2013Article
- Administration of MS-275 improves cognitive performance and reduces cell death following traumatic brain injury in rats.CNS neuroscience & therapeutics · 2013Article
- Expression of miRNAs and their cooperative regulation of the pathophysiology in traumatic brain injury.PloS one · 2012Article
- Cerebrovascular connexin expression: effects of traumatic brain injury.Journal of neurotrauma · 2011Article
- The effect of progesterone dose on gene expression after traumatic brain injury.Journal of neurotrauma · 2011Article
- Neuroproteomics: a biochemical means to discriminate the extent and modality of brain injury.Journal of neurotrauma · 2010Article
- Injury modality, survival interval, and sample region are critical determinants of qRT-PCR reference gene selection during long-term recovery from brain trauma.Journal of neurotrauma · 2009Article
- Traumatic brain injury alters expression of hippocampal microRNAs: potential regulators of multiple pathophysiological processes.Journal of neuroscience research · 2009Article
- Traumatic brain injury induces adipokine gene expression in rat brain.Neuroscience letters · 2008Article
- Traumatic brain injury stimulates hippocampal catechol-O-methyl transferase expression in microglia.Neuroscience letters · 2007Article
- Immunohistochemical analysis of histone H3 acetylation and methylation--evidence for altered epigenetic signaling following traumatic brain injury in immature rats.Brain research · 2006Article
- Genetic networks controlling retinal injury.Molecular vision · 2005Article
- Gene expression profiling in neurological disorders: toward a systems-level understanding of the brain.Neuromolecular medicine · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
It has been estimated that 50% of human transcriptome, the collection of mRNA in a cell, is expressed in the brain, making it one of the most complex organs to understand in terms of genomic responses to injury. The availability of genome sequences for several organisms coupled with the increasing affordability of microarray technologies makes it feasible to monitor the mRNA levels of thousands of genes simultaneously. In this paper, we provide an overview of findings using both cDNA- and oligonucleotide-based microarray analyses after experimental traumatic brain injury (TBI). Specifically, the utility of this methodology as a means of cataloging the biochemical sequelae of brain trauma and elucidating novel genes or pathways for further study is discussed. Furthermore, we offer future directions for the continued evaluation of microarray results and discuss the usefulness of microarray techniques as a testing format for determining the efficacy of mechanism-based therapies.
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15176484What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.