ArticleNeurochemical research2004
Gene expression of transcription factors in the rat brain after morphine withdrawal.
Article in Neurochemical research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Functional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studies.Molecular psychiatry · 2023Pooled it
- Chronic oxycodone induces integrated stress response in rat brain.BMC neuroscience · 2015Article
- Amphetamine up-regulates activator of G-protein signaling 1 mRNA and protein levels in rat frontal cortex: the role of dopamine and glucocorticoid receptors.Neuroscience · 2010Article
- Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake.Neuroscience · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple approaches have been performed to elucidate the molecular mechanisms underlying drug withdrawal in opioid-dependent animals. Opiate withdrawal represents a state of neuronal hyperexcitability in the brain that leads to alterations in a number of second-messenger systems which, in turn, induce expression of transcription factors. Whereas earlier studies have primarily demonstrated an early and transient transcriptional activation of members of the Fos, Jun, and Krox families, recent microarray studies investigating the delayed response could additionally identify several transcriptional repressors such as cAMP response element modulator (CREM), IkappaB, silencer factor B, helix-loop-helix proteins, or glucocorticoid-induced leucine zipper, indicating the attempt of the brain to re-establish homeostasis after withdrawal-induced excitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.