ArticleNeurochemical research2004
Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression.
Article in Neurochemical research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Glucose-Induced Transcriptional Hysteresis: Role in Obesity, Metabolic Memory, Diabetes, and Aging.Frontiers in endocrinology · 2018Review
- Regulation of peripheral metabolism by substrate partitioning in the brain.Endocrinology and metabolism clinics of North America · 2013Review
- Xenomitochondrial mice: investigation into mitochondrial compensatory mechanisms.Mitochondrion · 2011Article
- Hypothalamic responses to fasting indicate metabolic reprogramming away from glycolysis toward lipid oxidation.Endocrinology · 2010Article
- Effect of high-fat feeding on expression of genes controlling availability of dopamine in mouse hypothalamus.Nutrition (Burbank, Los Angeles County, Calif.) · 2010Article
- Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling.PLoS biology · 2009Article
- S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10.PloS one · 2009Article
- Genes associated with membrane-initiated signaling of estrogen and energy homeostasis.Endocrinology · 2008Article
- Effect of starvation on transcriptomes of brain and liver in adult female zebrafish (Danio rerio).Physiological genomics · 2008Article
- Secrets of the lac operon. Glucose hysteresis as a mechanism in dietary restriction, aging and disease.Interdisciplinary topics in gerontology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
DNA microarray analysis has been used to investigate relative changes in the level of gene expression in the CNS, including changes that are associated with disease, injury, psychiatric disorders, drug exposure or withdrawal, and memory formation. We have used oligonucleotide microarrays to identify hypothalamic genes that respond to nutritional manipulation. In addition to commonly used microarray analysis based on criteria such as fold-regulation, we have also found that simply carrying out multiple t tests then sorting by P value constitutes a highly reliable method to detect true regulation, as assessed by real-time polymerase chain reaction (PCR), even for relatively low abundance genes or relatively low magnitude of regulation. Such analyses directly suggested novel mechanisms that mediate effects of nutritional state on neuroendocrine function and are being used to identify regulated gene products that may elucidate the metabolic pathology of obese ob/ob, lean Vgf-/Vgf-, and other models with profound metabolic impairments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.