ArticleJournal of bacteriology2004
Structural basis for iron binding and release by a novel class of periplasmic iron-binding proteins found in gram-negative pathogens.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Hydrogel-based experimental models of the gastrointestinal tract.Microbiome · 2025Review
- Structural and functional insights into iron acquisition from lactoferrin and transferrin in Gram-negative bacterial pathogens.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- Iron Reduction inInternational journal of molecular sciences · 2022Article
- Structural dynamics in the evolution of a bilobed protein scaffold.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Structural and functional characterization of IdiA/FutA (Tery_3377), an iron-binding protein from the ocean diazotrophThe Journal of biological chemistry · 2018Article
- Exploring titanium(IV) chemical proximity to iron(III) to elucidate a function for Ti(IV) in the human body.Coordination chemistry reviews · 2018Article
- Article
- Real-Time Conformational Changes and Controlled Orientation of Native Proteins Inside a Protein Nanoreactor.Journal of the American Chemical Society · 2017Article
- Beyond iron: non-classical biological functions of bacterial siderophores.Dalton transactions (Cambridge, England : 2003) · 2015Review
- Review
- Ferric ion (hydr)oxo clusters in the "Venus flytrap" cleft of FbpA: Mössbauer, calorimetric and mass spectrometric studies.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2012Article
- A proteomic analysis of the regulon of the NarP two-component regulatory system response regulator in the bovine pathogen Mannheimia haemolytica A1.BMC research notes · 2011Article
- Expression, crystallization and preliminary X-ray analysis of a ferric binding protein from Thermus thermophilus HB8.Acta crystallographica. Section F, Structural biology and crystallization communications · 2011Article
- Photolysis of iron-siderophore chelates promotes bacterial-algal mutualism.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Coordination chemistry of bacterial metal transport and sensing.Chemical reviews · 2009Review
- Ligand-induced conformational changes in a thermophilic ribose-binding protein.BMC structural biology · 2008Article
- The role of the synergistic phosphate anion in iron transport by the periplasmic iron-binding protein from Haemophilus influenzae.The Biochemical journal · 2007Article
- Characterization of ferric and ferrous iron transport systems in Vibrio cholerae.Journal of bacteriology · 2006Article
- Diversity in ABC transporters: type I, II and III importers.Critical reviews in biochemistry and molecular biologyReview
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have determined the 1.35- and 1.45-A structures, respectively, of closed and open iron-loaded forms of Mannheimia haemolytica ferric ion-binding protein A. M. haemolytica is the causative agent in the economically important and fatal disease of cattle termed shipping fever. The periplasmic iron-binding protein of this gram-negative bacterium, which has homologous counterparts in many other pathogenic species, performs a key role in iron acquisition from mammalian host serum iron transport proteins and is essential for the survival of the pathogen within the host. The ferric (Fe(3+)) ion in the closed structure is bound by a novel asymmetric constellation of four ligands, including a synergistic carbonate anion. The open structure is ligated by three tyrosyl residues and a dynamically disordered solvent-exposed anion. Our results clearly implicate the synergistic anion as the primary mediator of global protein conformation and provide detailed insights into the molecular mechanisms of iron binding and release in the periplasm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.