ArticleThe Biochemical journal2004
Kinetics and control of oxidative phosphorylation in rat liver mitochondria after dexamethasone treatment.
Article in The Biochemical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- A meta-analysis of glucocorticoids as modulators of oxidative stress in vertebrates.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2011Pooled it
- Proteomic Profile of Skeletal Muscles and Liver in a Dexamethasone-Induced Atrophy Model: Insights into the Role of β-Hydroxy-β-Methylbutyrate on Contractile and Metabolic Protein.Cell biochemistry and biophysics · 2026Article
- (Un)Tying the Knot: Oxidative Stress, Inflammatory Markers, and Lipid Status in Dogs with Hypercortisolism.Animals : an open access journal from MDPI · 2024Article
- Review
- High-dose dexamethasone injection disordered metabolism and multiple protein kinases expression in the mouse kidney.Bioscience reports · 2021Article
- Mitochondrial Costs of Being Hot: Effects of Acute Thermal Change on Liver Bioenergetics in Toads (Frontiers in physiology · 2020Article
- Propofol infusion syndrome: a structured literature review and analysis of published case reports.British journal of anaesthesia · 2019Review
- The role of oxidative stress in anxiety disorder: cause or consequence?Free radical research · 2018Review
- Article
- Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity.Journal of clinical and translational research · 2017Article
- Lipid-induced thermogenesis is up-regulated by the first cold-water immersions in juvenile penguins.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- Glucocorticoid modulation of mitochondrial function in hepatoma cells requires the mitochondrial fission protein Drp1.Antioxidants & redox signaling · 2013Article
- Glucose sensing in the pancreatic beta cell: a computational systems analysis.Theoretical biology & medical modelling · 2010Article
- Vitamin C, resveratrol and lipoic acid actions on isolated rat liver mitochondria: all antioxidants but different.Redox report : communications in free radical research · 2010Article
- Insulin resistance is a cellular antioxidant defense mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Effect of muramyl peptides on mitochondrial respiration.Clinical and experimental immunology · 2009Article
- Effects of corticosteroids on oxidative damage and circulating carotenoids in captive adult kestrels (Falco tinnunculus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present investigation was undertaken in order to evaluate the contributions of ATP synthesis and proton leak reactions to the rate of active respiration of liver mitochondria, which is altered following dexamethasone treatment (1.5 mg/kg per day for 5 days). We applied top-down metabolic control analysis and its extension, elasticity analysis, to gain insight into the mechanisms of glucocorticoid regulation of mitochondrial bioenergetics. Liver mitochondria were isolated from dexamethasone-treated, pair-fed and control rats when in a fed or overnight fasted state. Injection of dexamethasone for 5 days resulted in an increase in the fraction of the proton cycle of phosphorylating liver mitochondria, which was associated with a decrease in the efficiency of the mitochondrial oxidative phosphorylation process in liver. This increase in proton leak activity occurred with little change in the mitochondrial membrane potential, despite a significant decrease in the rate of oxidative phosphorylation. Regulation analysis indicates that mitochondrial membrane potential homoeostasis is achieved by equal inhibition of the mitochondrial substrate oxidation and phosphorylation reactions in rats given dexamethasone. Our results also suggest that active liver mitochondria from dexamethasone-treated rats are capable of maintaining phosphorylation flux for cellular purposes, despite an increase in the energetic cost of mitochondrial ATP production due to increased basal proton permeability of the inner membrane. They also provide a complete description of the effects of dexamethasone treatment on liver mitochondrial bioenergetics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.