ArticlePediatric nephrology (Berlin, Germany)2004
Growth hormone therapy influences endothelial function in children with renal failure.
Article in Pediatric nephrology (Berlin, Germany), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Growth hormone in pediatric chronic kidney disease: more than just height.Pediatric nephrology (Berlin, Germany) · 2024Review
- Exogenous Growth Hormone Exacerbates Post-Irradiation Atherosclerosis in Susceptible Epicardial Coronary Arteries.Toxicologic pathology · 2024Article
- Covert actions of growth hormone: fibrosis, cardiovascular diseases and cancer.Nature reviews. Endocrinology · 2022Review
- Growth Hormone (GH) and Cardiovascular System.International journal of molecular sciences · 2018Review
- Cardiovascular disease in CKD in children: update on risk factors, risk assessment, and management.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2009Review
- Cardiovascular disease in children with CKD or ESRD.Nature reviews. Nephrology · 2009Review
- Flow-mediated vasodilatation of the brachial artery in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2008Article
- Arterial pulse wave velocity, inflammatory markers, pathological GH and IGF states, cardiovascular and cerebrovascular disease.Vascular health and risk management · 2008Review
- Assessment and treatment of short stature in pediatric patients with chronic kidney disease: a consensus statement.Pediatric nephrology (Berlin, Germany) · 2006Article
- Report of an NIH task force on research priorities in chronic kidney disease in children.Pediatric nephrology (Berlin, Germany) · 2006Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endothelial dysfunction, an early step in atherogenesis, is prevalent in children with renal insufficiency. Endothelial dysfunction in growth hormone deficiency is reversed by growth hormone (rhGH) therapy. Renal failure induces growth hormone resistance at the receptor and post-receptor level, which can be overcome by rhGH therapy. This study investigates the influence of rhGH therapy in children with renal failure on flow-mediated dilation (FMD) of the brachial artery, a marker of endothelial function. We studied 8 patients, who were on rhGH for at least 6 months, and 8 healthy children for comparison. FMD of the brachial artery was measured non-invasively as the percentage increase in diameter during post-ischemic hyperemia. Patients were studied at baseline, after 4 weeks interruption of rhGH therapy, and 4 weeks after resumption of therapy. FMD was significantly lower in patients (4.7%) than healthy controls (13.8%) ( P=0.01). During the administration of rhGH, FMD was significantly higher (3.9%) than during interruption of the treatment (1.4%) ( P=0.04). Our data support the theory that a disturbance in the GH-IGF axis contributes to the endothelial dysfunction of renal failure. Treatment with rhGH not only improves growth but may also favorably influence the risk for atherogenesis.
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