Evidence map›Paper›PMID 15173875›Full record

ReviewThe Journal of clinical investigation2004

Progress on new vaccine strategies for the immunotherapy and prevention of cancer.

Jay A Berzofsky, Masaki Terabe, SangKon Oh, Igor M Belyakov, Jeffrey D Ahlers, John E Janik, John C Morris

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 245 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Review
  5. Dendritic Cell Cancer Vaccines: A Focused Review.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  6. Current Landscape of Therapeutic Cancer Vaccines.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Exosomes in cancer therapy: a novel experimental strategy.American journal of cancer research · 2018
    Review
  17. Review
  18. Advances in Immunotherapy for Glioblastoma Multiforme.Journal of immunology research · 2017
    Review
  19. Multifunctional nanoparticles for cancer immunotherapy.Human vaccines & immunotherapeutics · 2016
    Review
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jay A BerzofskyMolecular Immunogenetics and Vaccine Research Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. berzofsk@helix.nih.gov
Masaki Terabe
SangKon Oh
Igor M Belyakov
Jeffrey D Ahlers
John E Janik
John C Morris
Center for Cancer Research · USNational Institute of Allergy and Infectious Diseases · US

Funding

Vaccine and immunotherapy strategies for cancer and viruses causing cancerZIASC004020 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI BERZOFSKY, JAY A · 2009 to 2025
$51.8M
Antigen-specific T-cell activation, vaccines for CancerZ01SC004020 · SC · DIVISION OF CLINICAL SCIENCES - NCI · PI BERZOFSKY, JAY A · 1996 to 2008
$3.8M
Cancer Vaccines and Modulation of Checkpoint Controls in ImmunizationZICBC010630 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JANIK, JOHN · 2009 to 2011
$1.8M
Cancer Vaccines and Modulation of Checkpoint Controls in ImmunizationZ01BC010630 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JANIK, JOHN · 2004 to 2008
$1.1M
RETROVIRAL VECTOR ENCODING A REVERSE TRANSCRIPTIONZ01SC010294 · SC · CLINICAL SCIENCES · PI MORRIS, JOHN C · 2000 to 2005
–
6 · The paper itself

Abstract

In recent years, great strides in understanding and regulating the immune system have led to new hope for harnessing its exquisite specificity to destroy cancer cells without affecting normal tissues. This review examines the fundamental immunologic advances and the novel vaccine strategies arising from these advances, as well as the early clinical trials studying new approaches to treat or prevent cancer.

Indexed as

Antigens, NeoplasmCancer VaccinesGenetic VectorsHumansImmunotherapyNeoplasmsVaccines, DNAVaccines, SubunitVirusesAntigens, NeoplasmCancer VaccinesVaccines, DNAVaccines, Subunit

Identifiers

PMID15173875
PMCPMC419494
OpenAlexW2158164086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.