ArticlePlant physiology2004
IAR4, a gene required for auxin conjugate sensitivity in Arabidopsis, encodes a pyruvate dehydrogenase E1alpha homolog.
Article in Plant physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- RNA mNature plants · 2025Review
- Diverse soil protists show auxin regulated growth in partnership with auxin-producing bacteria.The ISME journal · 2025Article
- PINOID-centered genetic interactions mediate auxin action in cotyledon formation.Plant direct · 2024Review
- TCA cycle impairment leads to PIN2 internalization and degradation via reduced MAB4 level and ARA6 components in Arabidopsis roots.Frontiers in plant science · 2024Article
- Recent advances in auxin biosynthesis and homeostasis.3 Biotech · 2023Review
- Non-canonical and developmental roles of the TCA cycle in plants.Current opinion in plant biology · 2023Review
- The diversity of substrates for plant respiration and how to optimize their use.Plant physiology · 2023Review
- Functional and comparative analysis ofPeerJ · 2023Article
- Transcriptome and Small RNA Sequencing Reveal the Mechanisms Regulating Harvest Index inFrontiers in plant science · 2022Article
- Mitochondrial Pyruvate Dehydrogenase Contributes to Auxin-Regulated Organ Development.Plant physiology · 2019Article
- Tryptophan Metabolism in Caenorhabditis elegans Links Aggregation Behavior to Nutritional Status.ACS chemical biology · 2019Article
- Arabidopsis IAR4 Modulates Primary Root Growth Under Salt Stress Through ROS-Mediated Modulation of Auxin Distribution.Frontiers in plant science · 2019Article
- Identification of the Candidate Proteins Related to Oleic Acid Accumulation during Peanut (International journal of molecular sciences · 2018Article
- Feedback Microtubule Control and Microtubule-Actin Cross-talk inMolecular & cellular proteomics : MCP · 2017Article
- Dissecting Seed Mucilage Adherence Mediated by FEI2 and SOS5.Frontiers in plant science · 2016Article
- Article
- Auxin biosynthesis and storage forms.Journal of experimental botany · 2013Review
- Quantitative phosphoproteome profiling of iron-deficient Arabidopsis roots.Plant physiology · 2012Article
- Localized auxin biosynthesis and postembryonic root development in Arabidopsis.Plant signaling & behavior · 2009Article
- Arabidopsis IAR4 modulates auxin response by regulating auxin homeostasis.Plant physiology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The formation and hydrolysis of indole-3-acetic acid (IAA) conjugates represent a potentially important means for plants to regulate IAA levels and thereby auxin responses. The identification and characterization of mutants defective in these processes is advancing the understanding of auxin regulation and response. Here we report the isolation and characterization of the Arabidopsis iar4 mutant, which has reduced sensitivity to several IAA-amino acid conjugates. iar4 is less sensitive to a synthetic auxin and low concentrations of an ethylene precursor but responds to free IAA and other hormones tested similarly to wild type. The gene defective in iar4 encodes a homolog of the E1alpha-subunit of mitochondrial pyruvate dehydrogenase, which converts pyruvate to acetyl-coenzyme A. We did not detect glycolysis or Krebs-cycle-related defects in the iar4 mutant, and a T-DNA insertion in the IAR4 coding sequence conferred similar phenotypes as the originally identified missense allele. In contrast, we found that disruption of the previously described mitochondrial pyruvate dehydrogenase E1alpha-subunit does not alter IAA-Ala responsiveness or confer any obvious phenotypes. It is possible that IAR4 acts in the conversion of indole-3-pyruvate to indole-3-acetyl-coenzyme A, which is a potential precursor of IAA and IAA conjugates.
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Registered trials
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