ArticleNucleic acids research2004
The highly conserved region of the co-repressor Sin3A functionally interacts with the co-repressor Alien.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Review
- Article
- A novel somatic mutation of SIN3A detected in breast cancer by whole-exome sequencing enhances cell proliferation through ERα expression.Scientific reports · 2018Article
- SIN3A, generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor.The Journal of biological chemistry · 2014Article
- Drosophila COP9 signalosome subunit 7 interacts with multiple genomic loci to regulate development.Nucleic acids research · 2014Article
- The ING tumor suppressors in cellular senescence and chromatin.Cell & bioscience · 2011Article
- The coregulator Alien.Nuclear receptor signaling · 2007Review
- The nucleosome assembly activity of NAP1 is enhanced by Alien.Molecular and cellular biology · 2007Article
- Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor.Cancer research · 2007Article
- Sin3: a flexible regulator of global gene expression and genome stability.Current genetics · 2005Review
- The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription.Nucleic acids research · 2005Article
- Sin3: master scaffold and transcriptional corepressor.Biochimica et biophysica actaReview
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Sin3 proteins are evolutionarily conserved co-repressors (CoR) that function as mediators of gene repression for a variety of transcriptional silencers. The paired amphipathic helices of Sin3A were identified and studied as protein-protein interacting domains. Previously we have shown the interaction of Sin3A with the CoR Alien in vivo and in vitro. Here, we show that Alien and Sin3A reside together in vivo with the vitamin D3 receptor on the human 24-hydroxylase (CYP24) promoter containing vitamin D3 response elements by chromatin immunoprecipitation. We delineated and characterized the interaction domains of Sin3A with Alien. Interestingly, the highly conserved region (HCR) of Sin3A, which has not yet been functionally characterized, interacts with Alien. The HCR encompasses only 134 amino acids, shares more than 80% identity with Sin3B and binds to the N-terminus of Alien, which harbours a transferable silencing function. Functionally, co-expression of Sin3A enhances Alien-mediated gene repression and overexpression of the HCR alone leads to the inhibition of Alien-mediated repression and to the induction of the endogenous CYP24 promoter. Our results therefore indicate a novel functional role of the Sin3 HCR and give novel insights into Alien-mediated gene repression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.