ArticleMolecular psychiatry2004
Acute amygdalar activation induces an upregulation of multiple monoamine G protein coupled pathways in rat hippocampus.
Article in Molecular psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Locus Ceruleus Norepinephrine Release: A Central Regulator of CNS Spatio-Temporal Activation?Frontiers in synaptic neuroscience · 2016Article
- Altered prefrontal cortical MARCKS and PPP1R9A mRNA expression in schizophrenia and bipolar disorder.Schizophrenia research · 2015Article
- Amygdalocortical circuitry in schizophrenia: from circuits to molecules.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Review
- Circuitry-based gene expression profiles in GABA cells of the trisynaptic pathway in schizophrenics versus bipolars.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- 5-HT6 receptor antagonist reversal of emotional learning and prepulse inhibition deficits induced by apomorphine or scopolamine.Pharmacology, biochemistry, and behavior · 2008Article
- N-cadherin regulates cytoskeletally associated IQGAP1/ERK signaling and memory formation.Neuron · 2007Article
- Patterns of gene expression in the limbic system of suicides with and without major depression.Molecular psychiatry · 2007Article
- Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia.Molecular psychiatry · 2006Article
- Mapping of hippocampal gene clusters regulated by the amygdala to nonlinkage sites for schizophrenia.Molecular psychiatry · 2006Article
- Regulation of synaptic plasticity in a schizophrenia model.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
A "partial" rodent model for schizophrenia has been used to characterize the regulation of hippocampal genes in response to amygdalar activation. At 96 h after the administration of picrotoxin into the basolateral nucleus, we have observed an increase in the expression of genes associated with 18 different monoamine (ie adrenergic alpha 1, alpha 2 and beta 2, serotonergic 5HT5b and 5HT6, dopamine D4 and muscarinic m1, m2 and m3) and peptide (CCK A and B, angiotensin 1A, mu and kappa opiate, FSH, TSH, LH, GNRH, and neuropeptide Y) G-protein coupled receptors (GPCRs). These latter receptors are associated with three different G protein signaling pathways (Gq, Gs, and Gi) in which significant changes in gene expression were also noted for adenylate cyclase (AC4), phosphodiesterase (PDE4D), protein kinase A (PKA), and protein kinase C (PKC). Quantitative RT-PCR was used to validate the results and demonstrated that there were predictable increases of three GPCRs selected for this analysis, including the dopamine D4, alpha 1b, and CCK-B receptors. Eight out of the nine monoamine receptors showing these changes have moderate to high affinity for the atypical antipsychotic, clozapine. Taken together, these results suggest that amygdalar activation may play a role in the pathophysiology and treatment of psychosis by regulating the activity of multiple GPCR and metabolic pathways in hippocampal cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.