ArticleThe pharmacogenomics journal2004
Linkage analysis of smoking initiation and quantity in Dutch sibling pairs.
Article in The pharmacogenomics journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of 15 genome-wide linkage scans of smoking behavior.Biological psychiatry · 2010Pooled it
- Investigating the Relationship Between Smoking Behavior and Global Brain Volume.Biological psychiatry global open science · 2024Article
- Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population.Lung cancer (Amsterdam, Netherlands) · 2016Article
- Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use.Genes, brain, and behavior · 2016Review
- Review
- Polygenic risk scores for smoking: predictors for alcohol and cannabis use?Addiction (Abingdon, England) · 2014Article
- The genetic architecture of liver enzyme levels: GGT, ALT and AST.Behavior genetics · 2013Article
- The CHRNA5-A3-B4 gene cluster in nicotine addiction.Molecular psychiatry · 2012Review
- Predicting nicotine dependence profiles among adolescent smokers: the roles of personal and social-environmental factors in a longitudinal framework.BMC public health · 2012Article
- Genetic analyses of smoking initiation, persistence, quantity, and age-at-onset of regular cigarette use in Brazilian families: the Baependi Heart Study.BMC medical genetics · 2012Article
- Glutamate and synaptic plasticity systems and smoking behavior: results from a genetic association study.PloS one · 2012Article
- A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families.The American journal of psychiatry · 2011Article
- Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2011Article
- Interplay between heritability of smoking and environmental conditions? A comparison of two birth cohorts.BMC public health · 2011Article
- OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models.Drug and alcohol dependence · 2010Review
- EEG alpha phenotypes: linkage analyses and relation to alcohol dependence in an American Indian community study.BMC medical genetics · 2010Article
- Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Genetic linkage findings for DSM-IV nicotine withdrawal in two populations.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2009Article
- Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2009Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
The heritability of smoking initiation (SI) and number of cigarettes smoked (NC) was determined in 3657 Dutch twin pairs. For SI a heritability of 36% was found and for NC of 51%. Both SI and NC were also significantly influenced by environmental factors shared by family members. The etiological factors that influence these traits partly overlap. Linkage analyses were performed on data of 536 DZ twins and siblings from 192 families, forming 592 sibling pairs. Results suggested QTLs on chromosome 6 (LOD=3.05) and chromosome 14 (LOD=1.66) for SI and on chromosome 3 (LOD=1.98) for NC. Strikingly, on chromosome 10 a peak was found in the same region for both SI (LOD=1.92) and for NC (LOD=2.29) which may partly explain the overlapping etiological factors for SI and NC.
Indexed as
Identifiers
15170444What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.