ArticleNature medicine2004
Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions.
Article in Nature medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
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- Decellularized bovine placentome for portacavally-interposed heterotopic liver transplantation in rats.Materials science & engineering. C, Materials for biological applications · 2019Article
- Decellularized human placenta supports hepatic tissue and allows rescue in acute liver failure.Hepatology (Baltimore, Md.) · 2018Article
- A Novel Endoscopic Bariatric Procedure: Results of an Experimental Study.Obesity surgery · 2016Article
- Silencing of hepatic fate-conversion factors induce tumorigenesis in reprogrammed hepatic progenitor-like cells.Stem cell research & therapy · 2016Article
- Cell therapy to remove excess copper in Wilson's disease.Annals of the New York Academy of Sciences · 2014Review
- Transdisciplinary approach to restore pancreatic islet function.Immunologic research · 2013Review
- Portocaval shunt for hepatocyte package: challenging application of small intestinal graft in animal models.Organogenesis · 2013Article
- Successful auto-implantation of hepatic cells in lung tissue: An animal study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013Article
- Long-term engraftment and function of transplanted pancreatic islets in vascularized segments of small intestine.Transplant international : official journal of the European Society for Organ Transplantation · 2011Article
Corrections and comments
- Expression of concern
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
We determine here the functional integrity of auxiliary livers in containers fashioned from the small intestine. Liver microfragments from dipeptidyl peptidase 4 (DPP4)-deficient rats were transplanted into syngeneic normal animals with isolated intestinal segments characterized by mucosal denudation but intact vascular supply. Transplanted liver fragments were restored to confluent tissue with normal hepatic architecture and development of DPP4-positive vessels, indicating angiogenesis and revascularization. Auxiliary liver units expressed multiple hepatotrophic and angiogenic genes, and transplanted tissues remained intact for up to the 6-week duration of the studies with neither ischemic injury nor significant hepatocellular proliferation. Hepatic metabolic, transport and synthetic functions were preserved in auxiliary livers, including uptake and biliary excretion of (99m)Tc-mebrofenin in syngeneic recipients of liver from F344 rats, as well as secretion of albumin in allografted Nagase analbuminemic rats. This ability to produce functionally competent auxiliary livers in vascularized intestinal segments offers therapeutic potential for liver disease and genetic deficiency.
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Registered trials
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