ArticleMolecular and cellular biology2004
Characterization of a mouse recombination hot spot locus encoding a novel non-protein-coding RNA.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Exploring the Characters of Non-Coding RNAs in Spermatogenesis and Male Infertility.International journal of molecular sciences · 2025Review
- Identification of PAX6 and NFAT4 as the Transcriptional Regulators of the Long Noncoding RNA Mrhl in Neuronal Progenitors.Molecular and cellular biology · 2022Article
- Regulation ofMolecular and cellular biology · 2022Article
- Fast and efficient generation of a full-length balancer chromosome by a single Cre/loxP recombination event.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Article
- Long Noncoding RNAs: Recent Insights into Their Role in Male Infertility and Their Potential as Biomarkers and Therapeutic Targets.International journal of molecular sciences · 2021Review
- LncRNA Hmrhl regulates expression of cancer related genes in chronic myelogenous leukemia through chromatin association.NAR cancer · 2021Article
- Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility.Reproductive biology and endocrinology : RB&E · 2020Review
- A novel enhancer RNA, Hmrhl, positively regulates its host gene,Non-coding RNA research · 2019Article
- DDX5/p68 associated lncRNA LOC284454 is differentially expressed in human cancers and modulates gene expression.RNA biology · 2018Article
- Advances of Long Noncoding RNAs-mediated Regulation in Reproduction.Chinese medical journal · 2018Review
- Regulatory role of long non-coding RNAs during reproductive disease.American journal of translational research · 2018Review
- Catsper1 promoter is bidirectional and regulates the expression of a novel lncRNA.Scientific reports · 2017Article
- Mrhl Long Noncoding RNA Mediates Meiotic Commitment of Mouse Spermatogonial Cells by Regulating Sox8 Expression.Molecular and cellular biology · 2017Article
- Mechanism of Wnt signaling induced down regulation of mrhl long non-coding RNA in mouse spermatogonial cells.Nucleic acids research · 2016Article
- Genome wide chromatin occupancy of mrhl RNA and its role in gene regulation in mouse spermatogonial cells.RNA biology · 2014Article
- mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells.Molecular and cellular biology · 2012Article
- Meiotic recombination hotspots of fission yeast are directed to loci that express non-coding RNA.PloS one · 2008Article
- The recombinational anatomy of a mouse chromosome.PLoS genetics · 2008Article
- A novel noncoding RNA processed by Drosha is restricted to nucleus in mouse.RNA (New York, N.Y.) · 2008Article
- Structural RNAs of known and unknown function identified in malaria parasites by comparative genomics and RNA analysis.RNA (New York, N.Y.) · 2007Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our current knowledge of recombination hot spot activity in mammalian systems implicates a role for both the primary DNA sequence and the nature of the chromatin domain around it. In mice, the only recombination hot spots mapped to date have been confined to a cluster within the major histocompatibility complex (MHC) region. We present a high resolution analysis of a new recombination hot spot in the mouse genome which maps to mouse chromosome 8 C-D. Haplotype diversity analysis across 40 different strains of mice has enabled us to map recombination breakpoints to a 1-kb interval. This hot spot has a recombination intensity that is 10- to 100-fold above the genome average and has a mean gene conversion tract length of 371 bp. This meiotically active locus happens to be flanked by a transcribed region encoding a non-protein-coding RNA polymerase II transcript and the previously characterized repair site. Many of the primary DNA sequence features that have been reported for the mouse MHC hot spots are also shared by this hot spot locus and in addition, along with three other MHC hot spot loci, we show a new parallel feature of association of the crossover sites with the nuclear matrix.
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