ArticleMolecular and cellular biology2004
SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 104 citations in OpenAlex.
- Inhibiting SHP2 improves ventricular remodeling by restoring AMPK phosphorylation and mitochondrial homeostasis.Cell communication and signaling : CCS · 2026Article
- SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis.Nature communications · 2024Article
- Setting sail: Maneuvering SHP2 activity and its effects in cancer.Advances in cancer research · 2023Review
- A comprehensive review of SHP2 and its role in cancer.Cellular oncology (Dordrecht, Netherlands) · 2022Review
- Phosphatase orphan 1 inhibits myoblast proliferation and promotes myogenic differentiation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Protein tyrosine phosphatase 11 acts through RhoA/ROCK to regulate eosinophil accumulation in the allergic airway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- SHP2 associates with nuclear localization of STAT3: significance in progression and prognosis of colorectal cancer.Scientific reports · 2017Article
- SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development.Oncotarget · 2016Article
- New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract.Cellular and molecular gastroenterology and hepatology · 2016Review
- Mining the function of protein tyrosine phosphatases in health and disease.Seminars in cell & developmental biology · 2015Review
- The role of the protein tyrosine phosphatase SHP2 in cardiac development and disease.Seminars in cell & developmental biology · 2015Review
- Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75 NTR.Neurotoxicology · 2014Article
- LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- PZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice.Molecular and cellular biology · 2014Article
- Oncogenic Shp2 disturbs microtubule regulation to cause HDAC6-dependent ERK hyperactivation.Oncogene · 2014Article
- SHP2 phosphatase promotes mast cell chemotaxis toward stem cell factor via enhancing activation of the Lyn/Vav/Rac signaling axis.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Cellular biochemistry methods for investigating protein tyrosine phosphatases.Antioxidants & redox signaling · 2014Review
- Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice.Disease models & mechanisms · 2013Article
- Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?The FEBS journal · 2013Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Myogenesis is an intricate process that coordinately engages multiple intracellular signaling cascades. The Rho family GTPase RhoA is known to promote myogenesis, however, the mechanisms controlling its regulation in myoblasts have yet to be fully elucidated. We show here that the SH2-containing protein tyrosine phosphatase, SHP-2, functions as an early modulator of myogenesis by regulating RhoA. When MyoD was expressed in fibroblasts lacking functional SHP-2, muscle-specific gene activity was impaired and abolition of SHP-2 expression by RNA interference inhibited muscle differentiation. By using SHP-2 substrate-trapping mutants, we identified p190-B RhoGAP as a SHP-2 substrate. When dephosphorylated, p190-B RhoGAP has been shown to stimulate the activation of RhoA. During myogenesis, p190-B RhoGAP was tyrosyl dephosphorylated concomitant with the stimulation of SHP-2's phosphatase activity. Moreover, overexpression of a catalytically inactive mutant of SHP-2 inhibited p190-B RhoGAP tyrosyl dephosphorylation, RhoA activity, and myogenesis. These observations strongly suggest that SHP-2 dephosphorylates p190-B RhoGAP, leading to the activation of RhoA. Collectively, these data provide a mechanistic basis for RhoA activation in myoblasts and demonstrate that myogenesis is critically regulated by the actions of SHP-2 on the p190-B Rho GAP/RhoA pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.