ArticleLearning & memory (Cold Spring Harbor, N.Y.)
Enhancement of inhibitory avoidance and conditioned taste aversion memory with insular cortex infusions of 8-Br-cAMP: involvement of the basolateral amygdala.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 81 citations in OpenAlex.
- Merkel cell stimulation in fear and sensory signaling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Still a "hidden island"? The rodent insular cortex in drug seeking, reward, and risk.Neuroscience and biobehavioral reviews · 2023Review
- Insula lesions reduce stimulus-driven control of behavior during odor-guided decision-making and autoshaping.Brain research · 2022Article
- Basolateral amygdala activation enhances object recognition memory by inhibiting anterior insular cortex activity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Taste Processing: Insights from Animal Models.Molecules (Basel, Switzerland) · 2020Review
- Glutamatergic basolateral amygdala to anterior insular cortex circuitry maintains rewarding contextual memory.Communications biology · 2020Article
- Disconnection of basolateral amygdala and insular cortex disrupts conditioned approach in Pavlovian lever autoshaping.Neurobiology of learning and memory · 2018Article
- Effects of lesions in different nuclei of the amygdala on conditioned taste aversion.Experimental brain research · 2017Article
- Picture free recall performance linked to the brain's structural connectome.Brain and behavior · 2017Article
- The Insula and Taste Learning.Frontiers in molecular neuroscience · 2017Review
- Activation of protein kinase A in the amygdala modulates anxiety-like behaviors in social defeat exposed mice.Molecular brain · 2016Article
- Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory.The Behavioral and brain sciences · 2016Article
- The basolateral amygdala in reward learning and addiction.Neuroscience and biobehavioral reviews · 2015Review
- Noradrenergic activation of the basolateral amygdala enhances object recognition memory and induces chromatin remodeling in the insular cortex.Frontiers in behavioral neuroscience · 2015Article
- Involvement of insular muscarinic cholinergic receptors in morphine-induced conditioned place preference in rats.Psychopharmacology · 2014Article
- Locus coeruleus neuromodulation of memories encoded during negative or unexpected action outcomes.Neurobiology of learning and memory · 2014Article
- Memory of conditioned taste aversion is erased by inhibition of PI3K in the insular cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Interacting brain systems modulate memory consolidation.Neuroscience and biobehavioral reviews · 2012Review
- The role of protein phosphorylation in the gustatory cortex and amygdala during taste learning.Experimental neurobiology · 2012Article
- Memory-enhancing intra-basolateral amygdala infusions of clenbuterol increase Arc and CaMKIIα protein expression in the rostral anterior cingulate cortex.Frontiers in behavioral neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
There is considerable evidence that in rats, the insular cortex (IC) and amygdala are involved in the learning and memory of aversively motivated tasks. The present experiments examined the effects of 8-Br-cAMP, an analog of cAMP, and oxotremorine, a muscarinic agonist, infused into the IC after inhibitory avoidance (IA) training and during the acquisition/consolidation of conditioned taste aversion (CTA). Posttraining infusion into the IC of 0.3 microg oxotremorine and 1.25 microg 8-Br-cAMP enhanced IA retention. Infusions of 8-Br-cAMP, but not oxotremorine, into the IC enhanced taste aversion. The experiments also examined whether noradrenergic activity in the basolateral amygdala (BLA) is critical in enabling the enhancement of CTA and IA memory induced by drug infusions administered into the IC. For both CTA and IA, ipsilateral infusions of beta-adrenergic antagonist propranolol administered into the BLA blocked the retention-enhancing effect of 8-Br-cAMP or oxotremorine infused into the IC. These results indicate that the IC is involved in the consolidation of memory for both IA and CTA, and this effect requires intact noradrenergic activity into the BLA. These findings provide additional evidence that the BLA interacts with other brain regions, including sensory cortex, in modulating memory consolidation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.