ReviewEuropean journal of pediatrics2004
Wegener granulomatosis in childhood and adolescence.
Review in European journal of pediatrics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 91 citations in OpenAlex.
- Granulomatosis with Polyangiitis: A Focus on Differences and Similarities Between Child and Adult Patients.Medicina (Kaunas, Lithuania) · 2025Review
- Plasma anti-PRTN3 IgG and IgM autoantibodies: novel biomarkers for early detection of lung adenocarcinoma.Frontiers in immunology · 2025Article
- An Unusual Presentation of Granulomatosis With Polyangiitis (Wegener's) After SARS-CoV-2 Infection.Cureus · 2023Article
- Hallmark trials in ANCA-associated vasculitis (AAV) for the pediatric rheumatologist.Pediatric rheumatology online journal · 2019Review
- Interleukin-32α promotes the proliferation of multiple myeloma cells by inducing production of IL-6 in bone marrow stromal cells.Oncotarget · 2017Article
- The Diagnosing Challenge of a Positive ANCA Vasculitis in the Paediatric Age.Case reports in pediatrics · 2017Article
- [Atypical presentation of granulomatosis with polyangiitis: about a pediatric observation].The Pan African medical journal · 2015Article
- Asymptomatic intracardiac mass in a 14-year-old girl with granulomatosis with polyangiitis: Case report.Pediatric rheumatology online journal · 2012Article
- Identification of the most active interleukin-32 isoform.Immunology · 2009Article
- Vasculitis in children and adolescents: clinical presentation, etiopathogenesis, and treatment.Paediatric drugs · 2009Review
- Article
- Chest CT findings in pediatric Wegener's granulomatosis.Pediatric radiology · 2007Article
- Proteinase 3 is an IL-32 binding protein.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wegener granulomatosis (WG) is a necrotising granulomatous small vessel vasculitis with a clinical predilection for involvement of the upper airways, lungs and kidneys, which occurs at all ages. The aetiology of WG, like other primary systemic vasculitides, remains unknown. Existing evidence suggests an autoimmune inflammatory process, characterised by early lesions with neutrophils and endothelial cells as active participants and involvement of antineutrophil cytoplasmatic antibodies (ANCA) directed against proteinase-3 (PR3). However, other concomitant factors like infections and environmental factors also appear to be necessary for the development of WG. In addition, multiple genetic factors seem to be involved in disease susceptibility. Whereas the first publications on WG in childhood were based on case reports, some studies in recent years allow to compare clinical findings, disease course, morbidity and mortality rates for childhood and adult onset patients. Whereas most aspects of WG are similar at all ages, some features appear to be significantly different. WG in childhood is more frequently complicated by subglottic stenosis and nasal deformity while treatment-related morbidity and malignancies are less common compared to adults. Introduction of combined treatment with cyclophosphamide and glucocorticoids resulted in a dramatic improvement of patient outcome; however, commonly occurring disease relapses and the risk of chronic organ damage at all ages make long-term follow-up of all patients and the establishment of new therapeutic regimens necessary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.