ArticleThe EMBO journal2004
Coupling between snoRNP assembly and 3' processing controls box C/D snoRNA biosynthesis in yeast.
Article in The EMBO journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Small Nucleolar RNAs (snoRNAs) in Cancer: From Biogenesis to Clinical Potential.OncoTargets and therapy · 2026Review
- Emerging Data on the Diversity of Molecular Mechanisms Involving C/D snoRNAs.Non-coding RNA · 2021Review
- The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity.Nature communications · 2021Article
- Bcd1p controls RNA loading of the core protein Nop58 during C/D box snoRNP biogenesis.RNA (New York, N.Y.) · 2019Article
- Transcription termination and the control of the transcriptome: why, where and how to stop.Nature reviews. Molecular cell biology · 2015Review
- Hepatitis C virus subverts liver-specific miR-122 to protect the viral genome from exoribonuclease Xrn2.Cell host & microbe · 2014Article
- TDP-43 regulates the microprocessor complex activity during in vitro neuronal differentiation.Molecular neurobiology · 2013Article
- Disengaging polymerase: terminating RNA polymerase II transcription in budding yeast.Biochimica et biophysica acta · 2013Review
- FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment.The EMBO journal · 2012Article
- Yeast Nrd1, Nab3, and Sen1 transcriptome-wide binding maps suggest multiple roles in post-transcriptional RNA processing.RNA (New York, N.Y.) · 2011Article
- Exon skipping and duchenne muscular dystrophy therapy: selection of the most active U1 snRNA antisense able to induce dystrophin exon 51 skipping.Molecular therapy : the journal of the American Society of Gene Therapy · 2010Article
- The scaRNA2 is produced by an independent transcription unit and its processing is directed by the encoding region.Nucleic acids research · 2010Article
- Fail-safe transcriptional termination for protein-coding genes in S. cerevisiae.Molecular cell · 2009Article
- Coupled RNA processing and transcription of intergenic primary microRNAs.Molecular and cellular biology · 2009Article
- Transcription termination by nuclear RNA polymerases.Genes & development · 2009Article
- Polyadenylation linked to transcription termination directs the processing of snoRNA precursors in yeast.Molecular cell · 2008Article
- Identification of genes that function in the biogenesis and localization of small nucleolar RNAs in Saccharomyces cerevisiae.Molecular and cellular biology · 2008Article
- The mRNA encoding the yeast ARE-binding protein Cth2 is generated by a novel 3' processing pathway.Nucleic acids research · 2008Article
- Inactivation of cleavage factor I components Rna14p and Rna15p induces sequestration of small nucleolar ribonucleoproteins at discrete sites in the nucleus.Molecular biology of the cell · 2008Article
- The structure and function of small nucleolar ribonucleoproteins.Nucleic acids research · 2007Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA polymerase II transcribes genes encoding proteins and a large number of small stable RNAs. While pre-mRNA 3'-end formation requires a machinery ensuring tight coupling between cleavage and polyadenylation, small RNAs utilize polyadenylation-independent pathways. In yeast, specific factors required for snRNA and snoRNA 3'-end formation were characterized as components of the APT complex that is associated with the core complex of the cleavage/polyadenylation machinery (core-CPF). Other essential factors were identified as independent components: Nrd1p, Nab3p and Sen1p. Here we report that mutations in the conserved box D of snoRNAs and in the snoRNP-specific factor Nop1p interfere with transcription and 3'-end formation of box C/D snoRNAs. We demonstrate that Nop1p is associated with box C/D snoRNA genes and that it interacts with APT components. These data suggest a mechanism of quality control in which efficient transcription and 3'-end formation occur only when nascent snoRNAs are successfully assembled into functional particles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.