ArticleDiabetologia1992
Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme.
Article in Diabetologia, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Estimation of Individual Positive Anti-Islet Autoantibodies from 3 Screen ICA Titer.International journal of molecular sciences · 2024Article
- Anti-Islet Autoantibodies in Type 1 Diabetes.International journal of molecular sciences · 2023Review
- Islet Autoantibodies in the Patients with Sjogren's Syndrome and Thyroid Disease and Risk of Progression to Latent Autoimmune Diabetes in Adults: A Case Series.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Purification of pituitary autoantigen by column liquid chromatography and chromatofocusing.Central-European journal of immunology · 2014Article
- Sequential elevation of autoantibodies to thyroglobulin and glutamic acid decarboxylase in type 1 diabetes.World journal of diabetes · 2013Article
- Predictors of associated autoimmune diseases in families with type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium.Diabetes/metabolism research and reviews · 2011Article
- Relationship of the 37,000- and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512).The Journal of clinical investigation · 1995Article
- Baclofen, a gamma-aminobutyric acid-b receptor agonist, delays diabetes onset in the non-obese diabetic mouse.Acta diabetologica · 1995Article
- Alterations of lymphocyte subsets in children of diabetic mothers.Diabetologia · 1994Article
- Article
- Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity.Diabetologia · 1994Article
- Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease.Diabetologia · 1994Article
- Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in stiff-man syndrome.The Journal of experimental medicine · 1993Article
- Prevalence of autoantibodies to the 65- and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus.The Journal of clinical investigation · 1993Article
- Detection of pancreatic islet 64,000 M(r) autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase.The Journal of clinical investigation · 1993Article
- Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression.The Journal of clinical investigation · 1993Article
- Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Human autoantibodies react with glutamic acid decarboxylase antigen in human and rat but not in mouse pancreatic islets.Diabetologia · 1993Article
- Article
- Autoantibodies in insulin-dependent diabetes mellitus.Journal of endocrinological investigationReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An islet protein of M(r) 64000, identified as the gamma-amino butyric acid (GABA)-synthesizing enzyme, glutamate decarboxylase, is a major target for antibodies in Type 1 (insulin-dependent) diabetes mellitus. This enzyme is also expressed in brain and in some other tissues and may exist in multiple forms. The aim of this study was to determine the ability of antibodies from diabetic patients to recognize glutamate decarboxylase from rat islets, brain and other normal rat tissues. Glutamate decarboxylase was detected at high activity levels in brain and at lower levels in islets, kidney, liver, pituitary gland, thyroid gland, adrenal gland, testis and ovary. The ability of antibodies in sera of diabetic patients to immunoprecipitate enzyme activity from detergent extracts of tissues was determined. Antibodies in sera from diabetic patients were found to bind the enzyme from islet and brain extracts, but bound less than 20% of the activity from other tissues. The ability of antibodies to immunoprecipitate the brain enzyme was significantly correlated with the presence of antibodies to the islet 64 kilodalton antigen. These studies show that the glutamate decarboxylase activity expressed in brain shares antigenic determinants with the islet 64 kilodalton antigen. Isoforms of the enzyme expressed in other non-neuronal tissues may be antigenically distinct and may lack determinants recognized by diabetes-associated antibodies.
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