ArticleGenetics2004
A large-scale screen for mutagen-sensitive loci in Drosophila.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
- An interdisciplinary, collaborative CURE to investigate mutagen-sensitive alleles inJournal of microbiology & biology education · 2025Article
- Division of Labor by the HELQ, BLM, and FANCM Helicases during Homologous Recombination Repair inGenes · 2022Article
- TheGenes · 2022Article
- Review
- TheG3 (Bethesda, Md.) · 2020Article
- Review
- Article
- A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case-control study.BMC cancer · 2014Article
- Helq acts in parallel to Fancc to suppress replication-associated genome instability.Nucleic acids research · 2013Article
- Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs.Nature communications · 2013Article
- A germline clone screen on the X chromosome reveals novel meiotic mutants in Drosophila melanogaster.G3 (Bethesda, Md.) · 2012Article
- Three structure-selective endonucleases are essential in the absence of BLM helicase in Drosophila.PLoS genetics · 2011Article
- Article
- Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila.PLoS genetics · 2010Article
- Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair.DNA repair · 2010Article
- Article
- Mammalian SNM1 is required for genome stability.Molecular genetics and metabolism · 2008Article
- MEN1 and FANCD2 mediate distinct mechanisms of DNA crosslink repair.DNA repair · 2008Article
- Article
- Multiple-pathway analysis of double-strand break repair mutations in Drosophila.PLoS genetics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a screen for new DNA repair mutants, we tested 6275 Drosophila strains bearing homozygous mutagenized autosomes (obtained from C. Zuker) for hypersensitivity to methyl methanesulfonate (MMS) and nitrogen mustard (HN2). Testing of 2585 second-chromosome lines resulted in the recovery of 18 mutants, 8 of which were alleles of known genes. The remaining 10 second-chromosome mutants were solely sensitive to MMS and define 8 new mutagen-sensitive genes (mus212-mus219). Testing of 3690 third chromosomes led to the identification of 60 third-chromosome mutants, 44 of which were alleles of known genes. The remaining 16 mutants define 14 new mutagen-sensitive genes (mus314-mus327). We have initiated efforts to identify these genes at the molecular level and report here the first two identified. The HN2-sensitive mus322 mutant defines the Drosophila ortholog of the yeast snm1 gene, and the MMS- and HN2-sensitive mus301 mutant defines the Drosophila ortholog of the human HEL308 gene. We have also identified a second-chromosome mutant, mus215(ZIII-2059), that uniformly reduces the frequency of meiotic recombination to <3% of that observed in wild type and thus defines a function required for both DNA repair and meiotic recombination. At least one allele of each new gene identified in this study is available at the Bloomington Stock Center.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.