ArticleGenetics2004
DNA variability and divergence at the notch locus in Drosophila melanogaster and D. simulans: a case of accelerated synonymous site divergence.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed.
- Molecular population genetics of Sex-lethal (Sxl) in the Drosophila melanogaster species group: a locus that genetically interacts with Wolbachia pipientis in Drosophila melanogaster.G3 (Bethesda, Md.) · 2021Article
- Article
- Variation in the Intensity of Selection on Codon Bias over Time Causes Contrasting Patterns of Base Composition Evolution in Drosophila.Genome biology and evolution · 2017Article
- Recent and Long-Term Selection Across Synonymous Sites in Drosophila ananassae.Journal of molecular evolution · 2016Article
- Evaluation of Ancestral Sequence Reconstruction Methods to Infer Nonstationary Patterns of Nucleotide Substitution.Genetics · 2015Article
- Adaptive evolution of genes involved in the regulation of germline stem cells in Drosophila melanogaster and D. simulans.G3 (Bethesda, Md.) · 2015Article
- Evaluating the ability of the pairwise joint site frequency spectrum to co-estimate selection and demography.Frontiers in genetics · 2015Article
- Genome diversity and divergence in Drosophila mauritiana: multiple signatures of faster X evolution.Genome biology and evolution · 2014Article
- The coevolutionary period of Wolbachia pipientis infecting Drosophila ananassae and its impact on the evolution of the host germline stem cell regulating genes.Molecular biology and evolution · 2014Article
- Genome-wide patterns of codon bias are shaped by natural selection in the purple sea urchin, Strongylocentrotus purpuratus.G3 (Bethesda, Md.) · 2013Article
- Strong purifying selection at synonymous sites in D. melanogaster.PLoS genetics · 2013Article
- Population genomic analysis of base composition evolution in Drosophila melanogaster.Genome biology and evolution · 2012Article
- Complex interplay of evolutionary forces in the ladybird homeobox genes of Drosophila melanogaster.PloS one · 2011Article
- A novel method to detect proteins evolving at correlated rates: identifying new functional relationships between coevolving proteins.Molecular biology and evolution · 2010Article
- Strong evidence for lineage and sequence specificity of substitution rates and patterns in Drosophila.Molecular biology and evolution · 2009Article
- Locus-specific decoupling of base composition evolution at synonymous sites and introns along the Drosophila melanogaster and Drosophila sechellia lineages.Genome biology and evolution · 2009Article
- Divergent patterns of selection on the DAB and DXB MHC class II loci in Xiphophorus fishes.Genetica · 2009Article
- Recurrent positive selection of the Drosophila hybrid incompatibility gene Hmr.Molecular biology and evolution · 2008Article
- Accelerated sequence divergence of conserved genomic elements in Drosophila melanogaster.Genome research · 2008Article
- Relationship between mRNA secondary structure and sequence variability in Chloroplast genes: possible life history implications.BMC genomics · 2008Article
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Authors and funding
4 authors.
Funding
Abstract
DNA diversity in two segments of the Notch locus was surveyed in four populations of Drosophila melanogaster and two of D. simulans. In both species we observed evidence of non-steady-state evolution. In D. simulans we observed a significant excess of intermediate frequency variants in a non-African population. In D. melanogaster we observed a disparity between levels of sequence polymorphism and divergence between one of the Notch regions sequenced and other neutral X chromosome loci. The striking feature of the data is the high level of synonymous site divergence at Notch, which is the highest reported to date. To more thoroughly investigate the pattern of synonymous site evolution between these species, we developed a method for calibrating preferred, unpreferred, and equal synonymous substitutions by the effective (potential) number of such changes. In D. simulans, we find that preferred changes per "site" are evolving significantly faster than unpreferred changes at Notch. In contrast we observe a significantly faster per site substitution rate of unpreferred changes in D. melanogaster at this locus. These results suggest that positive selection, and not simply relaxation of constraint on codon bias, has contributed to the higher levels of unpreferred divergence along the D. melanogaster lineage at Notch.
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