ReviewJournal of endocrinological investigation2004
New understanding of the role of cytokines in the pathogenesis of Graves' ophthalmopathy.
Review in Journal of endocrinological investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- RNA aptamers with specific binding affinity to CD40 (CD40Apt) represents a promising antagonist of the CD40-CD40L signaling for thyroid-associated ophthalmopathy (TAO) treatment in mouse.Journal of translational medicine · 2023Article
- Therapeutic Effect of α-MSH in Primary Cultured Orbital Fibroblasts Obtained from Patients with Thyroid Eye Disease.International journal of molecular sciences · 2021Article
- The thyroid, the eyes and the gut: a possible connection.Journal of endocrinological investigation · 2017Review
- Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease.International journal of endocrinology · 2015Article
- Association of IL12B polymorphisms with susceptibility to Graves ophthalmopathy in a Taiwan Chinese population.Journal of biomedical science · 2012Article
- In vitro study of antiadipogenic profile of latanoprost, travoprost, bimatoprost, and tafluprost in human orbital preadiopocytes.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2012Article
- Graves' ophthalmopathy: a review of immunogenetics.Current genomics · 2011Article
- Association of NFKB1 -94ins/del ATTG promoter polymorphism with susceptibility to and phenotype of Graves' disease.Genes and immunity · 2007Article
- Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat.The Journal of endocrinology · 2007Article
- Immunotherapy for Graves' orbitopathy: easy enthusiasm, but let's keep trying.Journal of endocrinological investigation · 2006Article
- Currently available somatostatin analogs are not good for Graves' orbitopathy.Journal of endocrinological investigation · 2006Article
- Insights into the role of fibroblasts in human autoimmune diseases.Clinical and experimental immunology · 2005Review
- Graves' ophthalmopathy: search for shared autoantigen(s) continues.Journal of endocrinological investigation · 2005Article
- Graves' ophthalmopathy: state of the art and perspectives.Journal of endocrinological investigation · 2004Review
- BIOINFORMATIC ANALYSIS IDENTIFIES POTENTIALLY KEY DIFFERENTIALLY EXPRESSED GENES AND PATHWAYS IN ORBITAL ADIPOSE TISSUES OF PATIENTS WITH THYROID EYE DISEASE.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokines play a key role in the development of Graves' ophthalmopathy (GO). These molecules are produced in the orbit of GO patients by infiltrating inflammatory cells as well as orbital fibroblasts. Locally produced cytokines stimulate fibroblast proliferation and their production of glycosaminoglycans, which result in accumulation of extracellular matrix and oedema with consequent proptosis. In addition to these direct effects, cytokines can modulate the immune reaction in GO by increasing major histocompatibility complex (MHC) class II, adhesion molecules, CD40, prostaglandin and heat shock protein expression in the orbit, thereby having a role in localising and augmenting the inflammatory response.
Indexed as
Identifiers
15164999What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.