ArticleJournal of neuro-oncology2004
Interstitial infusion of carmustine in the rat brain stem with systemic administration of O6-benzylguanine.
Article in Journal of neuro-oncology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma.Neurosurgery · 2020Article
- Convection-Enhanced Delivery for Diffuse Intrinsic Pontine Glioma Treatment.Current neuropharmacology · 2017Article
- The potential of theragnostic ¹²⁴I-8H9 convection-enhanced delivery in diffuse intrinsic pontine glioma.Neuro-oncology · 2014Article
- Magnetic resonance imaging properties of convective delivery in diffuse intrinsic pontine gliomas.Journal of neurosurgery. Pediatrics · 2014Article
- The effects of temozolomide delivered by prolonged intracerebral microinfusion against the rat brainstem GBM allograft model.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Article
- Gene therapy for late infantile neuronal ceroid lipofuscinosis: neurosurgical considerations.Journal of neurosurgery. Pediatrics · 2010Article
- Interstitial infusion of glioma-targeted recombinant immunotoxin 8H9scFv-PE38.Molecular cancer therapeutics · 2010Article
- Neurological grading, survival, MR imaging, and histological evaluation in the rat brainstem glioma model.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2009Article
- Local chemotherapy in the rat brainstem with multiple catheters: a feasibility study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2009Article
- Brain Stem Tumors.Current treatment options in neurology · 2005Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interstitial infusion of carmustine (BCNU) into the rat brain stem in conjunction with systemic administration of O6-benzylguanine (O6-BG) was performed in an effort to assess clinical tolerance. A total of 12 rats underwent stereotactic cannula placement into the pontine segment of the brain stem. Six of the rats underwent a 24-h infusion of BCNU (Volume of infusion [Vi] 200 microl) at its maximal concentrated dose (3.3 mg/ml) in 5% dextrose water. Six additional rats underwent 24-h infusion of BCNU preceded by an intraperitoneal injection of O6-BG at a dose of 50 mg/kg. Serial neurological examinations were performed on all animals. Histologic analyses were performed immediately or 2 weeks following sacrifice. Postoperatively, there were no neurological changes in any of the animals. Postmortem histological examination of the brains showed small pontine cavitary lesions (ranging from 20 to 250 microm) containing variable numbers of macrophages or neutrophils consistent with an inflammatory response. No changes beyond these findings indicated any histological evidence of injury. These finding were limited only to the cannula site and no changes beyond region of the cannula tract were found. These findings indicate that interstitial infusion of BCNU into the brain stem in conjunction with systemic administration of O6-BG is safe in a small animal and may serve as a potential investigative strategy for children with diffuse pontine gliomas.
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