Trial reportInternational journal of impotence research2004
Aging and pathogenesis of erectile dysfunction.
Trial report in International journal of impotence research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Epidemiology regarding penile prosthetic surgery.Asian journal of andrologyPooled it
- Efficacy and Safety of Avanafil in Chinese Subjects With Erectile Dysfunction: A Multi-Center, Randomized, Double-Blinded, Placebo-Controlled Phase III Clinical Trial.Sexual medicine · 2021Article
- Prevalence of Erectile Dysfunction and Associated Factors among Hypertensive Patients Attending Governmental Health Institutions in Gondar City, Northwest Ethiopia: A Cross-Sectional Study.International journal of hypertension · 2021Article
- Article
- Free testosterone correlated with erectile dysfunction severity among young men with normal total testosterone.International journal of impotence research · 2019Article
- A community-based study on prevalence and correlates of erectile dysfunction among Kinondoni District Residents, Dar Es Salaam, Tanzania.Reproductive health · 2016Article
- Testosterone deficiency in the aging male.Therapeutic advances in urology · 2016Review
- Short hairpin ribonucleic acid constructs targeting insulin-like growth factor binding protein-3 rehabilitated decreased testosterone concentrations in diabetic rats.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Anxiety and depression among Greek men with primary erectile dysfunction and premature ejaculation.Annals of general psychiatry · 2015Article
- Hypogonadal symptoms are associated with different serum testosterone thresholds in middle-aged and elderly men.Urology · 2014Article
- The effects of combined free radical scavenger and sildenafil therapy on age-associated erectile dysfunction: An animal model.Urology annals · 2014Article
- Comparison of the simplified International Index of Erectile Function (IIEF-5) in patients of erectile dysfunction with different pathophysiologies.BMC urology · 2014Article
- Effects of chronic treatment with the eNOS stimulator Impaza on penis length and sexual behaviors in rats with a high baseline of sexual activity.International journal of impotence research · 2014Article
- Testosterone is associated with erectile dysfunction: a cross-sectional study in Chinese men.PloS one · 2012Article
- Male late-onset hypogonadism: pathogenesis, diagnosis and treatment.Nature reviews. Urology · 2011Review
- Apoptosis of corpus cavernosum in patients with organic erectile dysfunction.World journal of urology · 2009Article
- The use of phosphodiesterase 5 inhibitors with concomitant medications.Journal of endocrinological investigation · 2008Review
- Which patients with sexual dysfunction are suitable for testosterone replacement therapy?Journal of endocrinological investigation · 2007Review
- Significance of hypogonadism in erectile dysfunction.World journal of urology · 2006Review
- Tadalafil in the treatment of erectile dysfunction; an overview of the clinical evidence.Clinical interventions in aging · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence and the severity of erectile dysfunction (ED) increase with advancing age; different pathogenetic factors could contribute to age-related ED. We studied organic, relational and intrapsychic components of ED as a function of patients' age in a consecutive series of 977 patients with ED, using the specifically designed structured interview SIEDY. A complete physical examination and a series of biochemical, hormonal, psychometric and penile vascular tests were also performed. Relational factors seems to be more relevant in patients aged over 60 y, while intrapsychic disturbances play a major role in younger subjects. Organic factors are the most important determinant of ED in all age groups, but their contribution is more important in older patients. In fact, basal and dynamic peak cavernosal velocity at Doppler ultrasound penile examination was reduced in older patients. Among hormonal factors, the body mass index-dependent reduction of testosterone in older patients does not seem to play a crucial role in the pathogenesis of ED. No significant correlation was observed between testosterone level and the severity of ED, although patients reporting hypoactive sexual desire showed significantly lower testosterone levels when compared with the rest of the sample. A better understanding of the relative contribution of age-related pathogenetic factors of ED could be of help in the design of appropriate therapeutic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.