ReviewJournal of clinical immunology2004
Inhibitory Fc gamma receptors: from gene to disease.
Review in Journal of clinical immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Fcγ Receptor Heterogeneity in Leukocyte Functional Responses.Frontiers in immunology · 2017Review
- Fc gamma receptor IIb on GM-CSF macrophages controls immune complex mediated inhibition of inflammatory signals.PloS one · 2014Article
- Ankylosing spondylitis: from cells to genes.International journal of inflammation · 2013Article
- FcγRIIb on liver sinusoidal endothelium clears small immune complexes.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fcγ receptor engagement.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- FcgammaRIIb inhibits allergic lung inflammation in a murine model of allergic asthma.PloS one · 2010Article
- Dependence of surface monoclonal antibody binding on dynamic changes in FcgammaRIIb expression.Immunology · 2008Article
- Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases.The Journal of clinical investigation · 2005Article
- Decreased transcription of the human FCGR2B gene mediated by the -343 G/C promoter polymorphism and association with systemic lupus erythematosus.Human genetics · 2005Article
- The polymorphisms -318C>T in the promoter and 49A>G in exon 1 of CTLA4 and the risk of aplastic anemia in a Caucasian population.Bone marrow transplantation · 2005Article
- Fc receptors and their role in immune regulation and autoimmunity.Journal of clinical immunology · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Multiple lines of evidence have revealed a key role for inhibitory Fc gamma receptors class IIb (FcgammaRIIb) as negative modulators of innate and adaptive immune responses. Acquired and genetic factors regulate the expression of FcgammaRIIb receptors and modify their inhibitory potential. Recent advances have highlighted the importance of FcgammaRIIb receptors in influencing the development of cancer and autoimmunity. The association of increased FcgammaRIIb expression with tumor development is believed to operate at effector cell level resulting in inhibition of antitumor cytotoxicity. In autoimmune diseases, FcgammaRIIb receptors play a major role in controlling the amplitude of antibody- and immune complex-mediated reactions. Generally, FcgammaRIIb deficiency is associated with increased susceptibility and severity to organ-specific and systemic autoimmunity. This article discusses the proposed mechanisms for FcgammaRIIb deregulation associated with malignant and autoimmune pathology in animal models and human diseases.
Indexed as
Identifiers
15163888What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.