ArticleJournal of virology2004
Nodamura virus nonstructural protein B2 can enhance viral RNA accumulation in both mammalian and insect cells.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Deciphering theVaccines · 2026Article
- Giant grouper nervous necrosis virus subgenomic RNA3 is transcribed by a premature termination mechanism via intragenomic RNA-RNA pairing.Virology journal · 2025Article
- Antiviral RNA interference in disease vector (Asian longhorned) ticks.PLoS pathogens · 2021Article
- Review
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- Biphasic regulation of RNA interference during rotavirus infection by modulation of Argonaute2.Cellular microbiology · 2019Article
- Review
- Diverse RNA viruses of arthropod origin in the blood of fruit bats suggest a link between bat and arthropod viromes.Virology · 2019Article
- Delivery of self-amplifying RNA vaccines in in vitro reconstituted virus-like particles.PloS one · 2019Article
- Enhanced susceptibility of cancer cells to oncolytic rhabdo-virotherapy by expression of Nodamura virus protein B2 as a suppressor of RNA interference.Journal for immunotherapy of cancer · 2018Article
- Evidence for Cross-Species Transmission of Covert Mortality Nodavirus to New Host ofFrontiers in microbiology · 2018Article
- Structure of a pentameric virion-associated fiber with a potential role in Orsay virus entry to host cells.PLoS pathogens · 2017Article
- Rapid evolution of virus sequences in intrinsically disordered protein regions.PLoS pathogens · 2014Article
- A unique nodavirus with novel features: mosinovirus expresses two subgenomic RNAs, a capsid gene of unknown origin, and a suppressor of the antiviral RNA interference pathway.Journal of virology · 2014Article
- Two membrane-associated regions within the Nodamura virus RNA-dependent RNA polymerase are critical for both mitochondrial localization and RNA replication.Journal of virology · 2014Article
- Steered molecular dynamics identifies critical residues of the Nodamura virus B2 suppressor of RNAi.Journal of molecular modeling · 2014Article
- Antiviral RNA interference in animals: piecing together the evidence.Nature structural & molecular biology · 2013Article
- Sindbis virus induces the production of a novel class of endogenous siRNAs in Aedes aegypti mosquitoes.Insect molecular biology · 2012Article
- Internal initiation is responsible for synthesis of Wuhan nodavirus subgenomic RNA.Journal of virology · 2011Article
- A 3' terminal stem-loop structure in Nodamura virus RNA2 forms an essential cis-acting signal for RNA replication.Virus research · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
During infection of both vertebrate and invertebrate cell lines, the alphanodavirus Nodamura virus (NoV) expresses two nonstructural proteins of different lengths from the B2 open reading frame. The functions of these proteins have yet to be determined, but B2 of the related Flock House virus suppresses RNA interference both in Drosophila cells and in transgenic plants. To examine whether the NoV B2 proteins had similar functions, we compared the replication of wild-type NoV RNA with that of mutants unable to make the B2 proteins. We observed a defect in the accumulation of mutant viral RNA that varied in extent from negligible in some cell lines (e.g., baby hamster kidney cells) to severe in others (e.g., human HeLa and Drosophila DL-1 cells). These results are consistent with the notion that the NoV B2 proteins act to circumvent an innate antiviral response such as RNA interference that differs in efficacy among different host cells.
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