Evidence map›Paper›PMID 15163760›Full record

ArticleJournal of virology2004

Postattachment events associated with viral entry are necessary for induction of interferon-stimulated genes by human cytomegalovirus.

James R Netterwald, Thomas R Jones, William J Britt, Shao-Jun Yang, Ian P McCrone, Hua Zhu

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Single-Cell Transcriptome Analysis of CD34Frontiers in microbiology · 2019
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Recognition of virus infection and innate host responses to viral gene therapy vectors.Molecular therapy : the journal of the American Society of Gene Therapy · 2010
    Review
  11. Article
  12. Article
  13. Article
  14. Multifaceted evasion of the interferon response by cytomegalovirus.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2009
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

James R NetterwaldDepartment of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, 225 Warren Streeet, Newark, NJ 07101-1709, USA.
Thomas R Jones
William J Britt
Shao-Jun Yang
Ian P McCrone
Hua Zhu
Rutgers, The State University of New Jersey · USUniversity of Alabama at Birmingham · US

Funding

ENVELOPE ASSEMBLY OF HUMAN CYTOMEGALOVIRUSR01AI035602 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRITT, WILLIAM JARVIS · 1995 to 2018
$4.5M
HCMV Glycoprotein B-Induced A Signal PathwayR01AI050709 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI ZHU, HUA · 2002 to 2006
$1.2M
NIAID NIH HHS AI 35602NIAID NIH HHS AO 50709-02A1NIAID NIH HHS R01 AI035602NIAID NIH HHS R01 AI050709
6 · The paper itself

Abstract

Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results indicate that ISG induction does not occur when virion-mediated, post-high-affinity attachment events are inhibited by either reagent. Thus, virion-mediated postattachment events, such as fusion, are required for ISG induction.

Indexed as

Gene Expression RegulationMembrane FusionCells, CulturedCytomegalovirusFibroblastsHumansInterferonsProteinsViral Envelope ProteinsVirionglycoprotein H, Cytomegalovirusglycoprotein H, Human cytomegalovirusInterferonsProteinsViral Envelope Proteins

Identifiers

PMID15163760
PMCPMC416537
OpenAlexW2159391559

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.