Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
An experiment of nature: brain anatomy parallels cognition and behavior in Williams syndrome.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
104 citing papers in PubMed, 269 citations in OpenAlex.
- Modeling Williams syndrome from a neurodevelopmental perspective: recent advances, model-based translational insights and future directions.World journal of pediatrics : WJP · 2026Review
- Associations between postnatal cerebral oxygen availability and utilization in very to late preterm infants and neurodevelopmental outcome.Scientific reports · 2026Observational
- Contrasting neurofunctional correlates of face- and visuospatial-processing in children and adolescents with Williams syndrome: convergent results from four fMRI paradigms.Scientific reports · 2024Article
- Internalising and Externalising Symptoms and Their Association with the Family Environment in Young Children with Williams Syndrome: A Longitudinal Study.Children (Basel, Switzerland) · 2023Article
- Distinct neuroanatomical and neuropsychological features of Down syndrome compared to related neurodevelopmental disorders: a systematic review.Frontiers in neuroscience · 2023Article
- Developmental changes in neural lateralization for visual-spatial function: Evidence from a line-bisection task.Developmental science · 2022Article
- Dissociation of early and late face-related processes in autism spectrum disorder and Williams syndrome.Orphanet journal of rare diseases · 2022Article
- Article
- Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs.Human brain mapping · 2022Review
- Amygdala connectivity and implications for social cognition and disorders.Handbook of clinical neurology · 2022Review
- Autism and Williams syndrome: truly mirror conditions in the socio-cognitive domain?International journal of developmental disabilities · 2022Review
- Williams syndrome: on the role of intellectual abilities in anxiety.Orphanet journal of rare diseases · 2021Article
- Is there collaboration specific neurophysiological activation during collaborative task activity? An analysis of brain responses using electroencephalography and hyperscanning.Brain and behavior · 2021Article
- Review
- A Critical Review of Spatial Abilities in Down and Williams Syndromes: Not All Space Is Created Equal.Frontiers in psychiatry · 2021Review
- Decreased density of cholinergic interneurons in striatal territories in Williams syndrome.Brain structure & function · 2020Article
- Interactive effects of age and recent substance use on striatal shape morphology at substance use disorder treatment entry.Drug and alcohol dependence · 2020Article
- Neuronal deletion of Gtf2i, associated with Williams syndrome, causes behavioral and myelin alterations rescuable by a remyelinating drug.Nature neuroscience · 2019Article
- [Hidden Markov models for human interactive behavior].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019Article
- Williams Syndrome, Human Self-Domestication, and Language Evolution.Frontiers in psychology · 2019Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Williams syndrome (WS) is a neurogenetic-neurodevelopmental disorder characterized by a highly variable and enigmatic profile of cognitive and behavioral features. Relative to overall intellect, affected individuals demonstrate disproportionately severe visual-spatial deficits and enhanced emotionality and face processing. In this study, high-resolution magnetic resonance imaging data were collected from 43 individuals with WS and 40 age- and gender-matched healthy controls. Given the distinct cognitive-behavioral dissociations associated with this disorder, we hypothesized that neuroanatomical integrity in WS would be diminished most in regions comprising the visual-spatial system and most "preserved" or even augmented in regions involved in emotion and face processing. Both volumetric analysis and voxel-based morphometry were used to provide convergent approaches for detecting the hypothesized WS neuroanatomical profile. After adjusting for overall brain volume, participants with WS showed reduced thalamic and occipital lobe gray matter volumes and reduced gray matter density in subcortical and cortical regions comprising the human visual-spatial system compared with controls. The WS group also showed disproportionate increases in volume and gray matter density in several areas known to participate in emotion and face processing, including the amygdala, orbital and medial prefrontal cortices, anterior cingulate, insular cortex, and superior temporal gyrus. These findings point to specific neuroanatomical correlates for the unique topography of cognitive and behavioral features associated with this disorder.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.