ArticleDevelopment (Cambridge, England)2004
Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues.
Article in Development (Cambridge, England), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- A Comparative Analysis of the Gene Expression Profiles in the Mammary Glands of Lactating and Nonlactating Mares at the Second Month of Gestation.Animals : an open access journal from MDPI · 2024Article
- Epithelial-adipocyte interactions are required for mammary gland development, but not for milk production or fertility.Developmental biology · 2020Article
- Milk lipid regulation at the maternal-offspring interface.Seminars in cell & developmental biology · 2018Review
- Role of Phospholipid Flux during Milk Secretion in the Mammary Gland.Journal of mammary gland biology and neoplasia · 2017Review
- Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases.Journal of lipid research · 2017Article
- Biological underpinnings of breastfeeding challenges: the role of genetics, diet, and environment on lactation physiology.American journal of physiology. Endocrinology and metabolism · 2016Review
- Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation.PloS one · 2016Article
- Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolism.Journal of lipid research · 2015Review
- Genome-wide detection of selective signatures in Simmental cattle.Journal of applied genetics · 2014Article
- Thyroid hormone responsive protein Spot14 enhances catalysis of fatty acid synthase in lactating mammary epithelium.Journal of lipid research · 2014Article
- Milk lipid secretion: recent biomolecular aspects.Biomolecular concepts · 2012Article
- RNA interference-mediated knockdown of DGAT1 decreases triglyceride content of bovine mammary epithelial cell line.Gene expression · 2012Article
- Article
- Lipid droplets and cellular lipid metabolism.Annual review of biochemistry · 2012Review
- Adipophilin regulates maturation of cytoplasmic lipid droplets and alveolae in differentiating mammary glands.Journal of cell science · 2011Article
- Murine diacylglycerol acyltransferase-2 (DGAT2) can catalyze triacylglycerol synthesis and promote lipid droplet formation independent of its localization to the endoplasmic reticulum.The Journal of biological chemistry · 2011Article
- Mammary ductal growth is impaired in mice lacking leptin-dependent signal transducer and activator of transcription 3 signaling.Endocrinology · 2010Article
- Article
- Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin.The Journal of biological chemistry · 2009Article
- Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.Journal of lipid research · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Mammary gland development is a complex process that is dependent on interactions between the developing mammary epithelium and the surrounding stromal tissues. We show that mice lacking the triglyceride synthesis enzyme acyl CoA:diacylglycerol transferase 1 (DGAT1) have impaired mammary gland development, characterized by decreased epithelial proliferation and alveolar development, and reduced expression of markers of functional differentiation. Transplantation studies demonstrate that the impaired development results from a deficiency of DGAT1 in both the stromal and epithelial tissues. Our findings are the first to link defects in stromal lipid metabolism to impaired mammary gland development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.